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Klappentext Covers the spectrum of biology! physiology! and clinical information! from molecular biology to public health concerns in developing countries. This title includes detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; and! psychiatric and medical comorbidity. Zusammenfassung Covers the spectrum of biology! physiology! and clinical information! from molecular biology to public health concerns in developing countries. This title includes detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; and! psychiatric and medical comorbidity. Inhaltsverzeichnis VOLUME I Introduction: What Is Epilepsy? SECTION 1 EPIDEMIOLOGY! PATHOLOGY! AND GENETICS OF EPILEPSY Overview: Epidemiology! Pathology! and Genetics Epilepsy: Historical Perspectives Neuropathology EPIDEMIOLOGY Incidence and Prevalence The Natural History and Prognosis of Epilepsy NEUROPATHOLOGY General Neuropathology of Epilepsy Hippocampal Sclerosis GENETICS Genetic Epidemiology EEG Traits SECTION II THE NEUROBIOLOGY OF EPILEPSY Overview: The Neurobiology of Epilepsy MECHANISMS OF NORMAL NEURONAL EXCITABILITY Control of Neuronal Excitability Excitatory Synaptic Transmission Neocortical Anatomy and Physiology Thalamocortical Anatomy and Physiology MECHANISMS OF EPILEPTOGENESIS AND EPILEPTOGENICITY Genetic Models of Epilepsy Seizure Mechanisms and Vulnerability in the Developing Brain SECTION III PHENOMENOLOGY Overview: Phenomenology EPILEPTIC SEIZURES Simple Motor Seizures Limbic Seizures Epileptic Spasms STATUS EPILEPTICUS Generalized Convulsive Status Epilepticus Absence Status Epilepticus Myoclonic Status Epilepticus EPILEPTIC DISORDERS Classification of the Epilepsies SECTION IV DIAGNOSTIC EVALUATION Overview: Diagnostic Evaluation ROUTINE INVESTIGATIONS History and Physical Examination EEG Physiologic Basis of the Electroencephalogram and Local Field Potentials Ictal Electroencephalogram Polygraphic Recordings NEUROIMAGING Positron Emission Tomography Magnetic Resonance Spectroscopy Computational Anatomy NEW DIRECTIONS Seizure Prediction Microdialysis Transcranial Magnetic Stimulation Cellular Imaging of Epilepsy NEUROPSYCHOLOGICAL EVALUATION LONG-TERM MONITORING VOLUME II SECTION V GENERAL TREATMENT CONSIDERATIONS Overview: General Approaches to Treatment GENERAL CONSIDERATIONS PRINCIPLES OF DRUG TREATMENT STRATEGIES FOR PHARMACOTHERAPY SPECIAL THERAPEUTIC CONSIDERATIONS ALTERNATIVE APPROACHES SECTION VI ANTIEPILEPTIC DRUGS ANTIEPILEPTIC DRUG DEVELOPMENT ANTIEPILEPTIC DRUGS SECTION VII SURGICAL THERAPY CANDIDATE SELECTION INVASIVE MONITORING TECHNIQUES FUNCTIONAL MAPPING TECHNIQUES THERAPEUTIC SURGICAL PROCEDURES POSTOPERATIVE FOLLOW-UP SECTION VIII CLINICAL BIOLOGY OF EPILEPSY BIORHYTHMS AND THE AUTONOMIC NERVOUS SYSTEM COMORBIDITY NEUROENDOCRINOLOGY VOLUME III SECTION IX PSYCHIATRIC AND SOCIAL ISSUES PSYCHIATRIC ISSUES SOCIAL ISSUES SECTION X EPILEPSY SYNDROMES NEONATAL SYNDROMES SYNDROMES OF INFANCY AND EARLY CHILDHOOD SYNDROMES OF LATER CHILDHOOD AND ADOLESCENCE NON AGE-RELATED AND SPECIAL SYNDROMES DISEASES ASSOCIATED WITH EPILEPSY SECTION XI DISORDERS THAT CAN BE CONFUSED WITH EPILEPSY SYSTEMIC DISTURBANCES NEUROLOGICAL DISTURBANCES PSYCHIATRIC DISTURBANCES SECTION XII DELIVERY OF HEALTH CARE AND SOCIOECONOMIC ISSUES ORGANIZATION OF HEALTH CARE IN DIFFERENT COUNTRIES SPECIALIZED CENTERS FOR EPILEPSY COST AND ALLOCATION OF RESOURCES Subject Index ...
