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This book is important for those interested in cholinergic synaptic transmission, the central and peripheral cholinergic nervous systems, neuropharmacology, cholinergic brain function, human and animal behaviors including learning, aggression and self-awareness, anticholinesterases and war gases, and the associated neurological diseases and aging.
List of contents
Introduction: History and Scope of this Book.
- Cholinergic Cells and Pathways.
- Metabolism of Acetylcholine Synthesis and Turnover.
- History of Research on Nicotinic and Muscarinic Receptors.
- MuscarinicAcetylcholine Receptors in the Central Nervous System: Structure, Function and Pharmacology.
- Neuronal Nicotinic Receptors: Structure and Functional Roles.
- Anticholinesterases and War Gases.
- Cholinergic Aspects of Growth and Development.
- Central Cholinergic Nervous System and Its Correlates.
- Linking Amyloid and Tau Biology in Alzheimer's Disease and Its Cholinergic Aspects.
- Envoi.
Summary
Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.
