Fr. 236.00

Biology and Physiology of the Blood-Brain Barrier

English · Hardback

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Description

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The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

List of contents

Introductory Overviews.- I: Physiological Transports through the Blood-Brain Barrier.- II: Blood-Brain Barrier and Drug Delivery to the Brain.- III: Multidrug Resistance P-Glycoprotein at the Blood-Brain Barrier.- IV: Signal Transduction in Brain Endothelial Cells.- V: Interactions-Leukocytes-Brain Endothelial Cells.- VI: Brain Pathologies and Blood-Brain Barrier.

Summary

Proceedings of the Cerebral Vascular Biology Symposium held in Paris, France, July 10-12, 1995

Product details

Assisted by Pierre-Olivie Couraud (Editor), Pierre-Olivier Couraud (Editor), Scherman (Editor), Scherman (Editor), Daniel Scherman (Editor)
Publisher Springer, Berlin
 
Languages English
Product format Hardback
Released 30.06.2009
 
EAN 9780306453625
ISBN 978-0-306-45362-5
No. of pages 388
Weight 998 g
Illustrations XVI, 388 p.
Series Advances in Behavioral Biology
Advances in Behavioral Biology
Subject Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine

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