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Zusatztext ". . . written in an accessible style! explain scientifically complex aspects of modern drug discovery research in a concise manner! and are by and large well referenced! thereby providing the reader with a sound basis for further studies . . . to a drug-discovery-oriented audience! it certainly has a number of interesting things to offer and is a meaningful addition to a series of drug discovery publications." - Jürgen Bajorath! University of Bonn! in ChemMedChem! 2008! No. 3"This book will be of interest to medicinal chemists and other pharmaceutical scientists involved in expanding their knowledge of rapidly evolving functional informative techniques . . . The chapters are quite readable! relatively free of typographical errors! and well referenced to work published up to 2004. There is a good subject index." - Peter Gund! Gund Discovery Services! in Journal of Medicinal Chemistry! 2008! Vol. 51! No. 8 Informationen zum Autor Ilyin\! Sergey Klappentext This volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities. It presents automation approaches for collecting and analyzing biological data and explains how to use PD biomarkers to accelerate drug development. The book also reviews a variety of novel drug discovery approaches presently used at Johnson & Johnson! and discusses the clinical successes of antibody therapeutics for treating oncology cases. In addition! it offers an integrated approach to identify relevant target genes for drug discovery and explores the application of laser microdissection in transcriptomics. Zusammenfassung This volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities. It presents automation approaches for collecting and analyzing biological data and explains how to use PD biomarkers to accelerate drug development. The book also reviews a variety Inhaltsverzeichnis PrefaceIntelligent AutomationJames M. DixonNeurally Inspired Algorithms as Computational ToolsMark Flynn and Garrett T. KenyonUsing Pharmacodynamic Biomarkers to Accelerate Early Clinical Drug DevelopmentOle VesterqvistOpportunities in CNS Drug Discovery and DevelopmentAlbert Pinhasov! Anil H. Vaidya! Hong Xin! Daniel Horowitz! Daniel Rosenthal! Douglas E. Brenneman! Ewa Malatynska! Sergey E. Ilyin! and Carlos R. Plata-SalamánClinical Success of Antibody Therapeutics in Oncology Bernard J. Scallon! Linda A. Snyder! G. Mark Anderson! Qiming Chen! Li Yan! and Marian T. NakadaRelating Target Sequence to Biological FunctionGreg M. ArndtUse of Protein Microarrays for Molecular Network Analysis and Signal-Pathway ProfilingKatherine R. Calvo! Lance A. Liotta! and Emanuel F. PetricoinLaser Microdissection-Based Transcriptomics Using Microarrays Fredrik Kamme! Berndt Meurers! Jessica Zhu! Da-Thao Tran! Jingxue Yu! Changlu Liu! Andrew Carmen! and Bingren HuIndex ...
