Biomacromolecules - Introduction to Structure, Function and Informatics

Informationen zum Autor C. STAN TSAI , PhD, served for more than twenty years as a professor of chemistry and biochemistry at Carleton University, Canada. He is the author of An Introduction to Computational Biochemistry , also from Wiley. Klappentext The structure and function of biomacromolecules elucidated by the latest advances in informaticsThis text provides an integrated presentation of the structure and function of nucleic acids, proteins, and glycans, including the latest findings from the fields of genomics, proteomics, and glycomics. It serves as a bridge between introductory biochemistry textbooks and advanced treatises on individual classes of biomacromolecules. The integrated treatment of biomacromolecules enables the reader to gain a better understanding and appreciation of both the similarities and differences among the three classes of biomacromolecules examined in the text.The content and structure of the text reflects the author's almost forty years' experience in researching, teaching, and publishing on the topic of biomacromolecules. Following three chapters that set a solid foundation of fundamentals, the text covers:* Biomacromolecular structure of nucleic acids, proteins, and polysaccharides* Studies of biomacromolecular structures, including spectroscopic analysis ofconformation, chemical synthesis, and computation and modeling* Functions of biomacromolecules, including their interactions, catalyses, and metabolisms* Informatics, including genomics, proteomics, and glycomics* Biomacromolecular evolutionContent follows the organization of an introductory biochemistry textbook, enabling instructors and students to easily integrate the text into a course. Each chapter includes a list of print and online references that serves as a gateway to further study.This text is designed for students who are moving beyond an introductory level in biochemistry towards the advanced fields of study in genomics, proteomics, or glycomics. Advanced mathematical and computational skills are not needed. Zusammenfassung This book is the first to offer an integrated, comprehensive overview of the structure and function of biomacromolecules together with a summary of the latest advances from bioinformatics and functional genomics. Inhaltsverzeichnis Preface. Abbreviations in Repetitive Use. CHAPTER 1. INTRODUCTION. 1.1 Prelude. 1.2 Covalent Bonds. 1.3 Noncovalent Interactions. 1.4 Isomerism: Configuration versus Conformation. 1.5 Trilogy. 1.6 References. CHAPTER 2. MONOMER CONSTITUENTS OF BIOMACROMOLECULES. 2.1 Nucleotides: Constituents of Nucleic Acids. 2.2 á-Amino Acids: Constituents of Proteins. 2.3 Monosaccharides: Constituents of Glycans. 2.4 Addendum. 2.5 References. CHAPTER 3. PURIFICATION AND CHARACTERIZATION. 3.1 Purification: Overview. 3.2 Purification: Chromatography. 3.3 Purification: Electrophoresis. 3.4 Characterization: General. 3.6 References. CHAPTER 4. BIOMACROMOLECULAR STRUCTURE: NUCLEIC ACIDS. 4.1 Structural Organization. 4.2 Sequence Analysis of Nucleic Acids. 4.3 Secondary Structure and Structure Polymorphism of DNA. 4.4 Supercoiling and Tertiary Structure of DNA. 4.5 Classification and Structures of RNA. 4.6 RNA Folds and Structure Motifs. 4.7 Energetics of Nucleic Acid Structure. 4.8 Nucleic Acid Application. 4.9 References. CHAPTER 5. BIOMACROMOLECULAR STRUCTURE: PROTEINS. 5.1 Architecture of Protein Molecules. 5.2 Primary Structure of Proteins: Chemical and Enzymatic Sequence Analysis. 5.3 Primary Structure of Proteins: Sequence Analysis by Tandem Mass Spectrometry. 5.4 Conformational Map. 5.5 Secondary Structures and Motifs of Proteins. 5.6 Domains and...

List of contents

Preface.
 
Abbreviations in Repetitive Use.
 
CHAPTER 1. INTRODUCTION.
 
CHAPTER 2. MONOMER CONSTITUENTS OF BIOMACROMOLECULES.
 
CHAPTER 3. PURIFICATION AND CHARACTERIZATION.
 
CHAPTER 4. BIOMACROMOLECULAR STRUCTURE: NUCLEIC ACIDS.
 
CHAPTER 5. BIOMACROMOLECULAR STRUCTURE: PROTEINS.
 
CHAPTER 6. BIOMACROMOLECULAR STRUCTURE: POLYSACCHARIDES.
 
CHAPTER 7. STUDIES OF BIOMACROMOLECULAR STRUCTURES: SPECTROSCOPIC ANALYSIS OF CONFORMATION.
 
CHAPTER 8. STUDIES OF BIOMACROMOLECULAR STRUCTURES: CHEMICAL SYNTHESIS.
 
CHAPTER 9. STUDIES OF BIOMACROMOLECULAR STRUCTURES: COMPUTATION AND MODELING.
 
CHAPTER 10. BIOMACROMOLECULAR INTERACTION.
 
CHAPTER 11. BIOMACROMOLECULAR CATALYSIS.
 
CHAPTER 12. SIGNAL TRANSDUCTION AND BIODEGRADATION.
 
CHAPTER 13. BIOSYNTHESIS AND GENETIC TRANSMISSION.
 
CHAPTER 14. BIOMACROMOLECULAR INFORMATICS.
 
CHAPTER 15. GENOMICS.
 
CHAPTER 16. PROTEOMICS.
 
CHAPTER 17. GLYCOMICS.
 
CHAPTER 18. BIOMACROMOLECULAR EVOLUTION.
 
INDEX.

Report

"[The book] covers, in 18 chapters, most of what one would ever want to know about macromolecules structure and functions." ( Biotechnology Journal , June 2008)

Product details

• Authors: C Stan Tsai, C. St. Tsai, C. Stan Tsai, C. Stan (Department of Chemistry Tsai, C.stan Tsai, CS Tsai, TSAI C STAN
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 24.11.2006
• EAN: 9780471713975
• ISBN: 978-0-471-71397-5
• No. of pages: 768
• Subjects: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics; Molekularbiologie, Science, SCIENCE / Life Sciences / Biochemistry, SCIENCE / Life Sciences / Molecular Biology