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In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.
List of contents
CHANGING EXTRACELLULAR MATRIX LIGANDS DURING METASTASIS.- SUPPRESSION AND ALTERATION OF ADHESION STRUCTURES IN HUMAN EPITHELIAL CANCER PROGRESSION.- REGULATION OF CADHERINS DURING PROSTATE CANCER PROGRESSION.- THE ACTIN CYTOSKELETON AND METASTASIS.- CHARACTERIZATION OF THE FERM DOMAIN PROTEIN EHM2 IN HUMAN CANCER CELLS.- CYTOKERATIN 6 EXPRESSION IN PROSTATE STEM CELLS.- EPIGENETIC REGULATION OF GENES THAT AFFECT TUMOR CELL ADHESION.- CELL ADHESION-MEDIATED RADIATION RESISTANCE: THE ROLE OF INTEGRINS AND INTEGRIN PROXIMAL PROTEIN.- CAM-DR: HANGING ON FOR CELL SURVIVAL.- EPITHELIAL CELL SURFACE TARGETING USING SYNTHETIC D-AMINO ACID PEPTIDES.
Summary
In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.
