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Informationen zum Autor METIN AKAY , PHD, is the Interim Chair and Professor of Bioengineering for the Harrington Department of Bioengineering at the Arizona State University. Dr. Akay is the founding Series Editor of the IEEE Press Series on Biomedical Engineering. In 1997, he received the prestigious Early Career Achievement Award from the IEEE Engineering in Medicine and Biology Society (EMBS). He was the program chair of both the annual IEEE EMBS Conference and Summer School for 2001. Dr. Akay has published several papers in the field and authored, coauthored, or edited fourteen books. He is also the editor in chief of the Wiley Encyclopedia of Biomedical Engineering . Klappentext Current applications and recent advances in genomics and proteomicsGenomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding.Topics discussed include:* Qualitative knowledge models* Interpreting micro-array data* Gene regulation bioinformatics* Methods to analyze micro-array* Cancer behavior and radiation therapy* Error-control codes and the genome* Complex life science multi-database queries* Computational protein analysis* Tumor and tumor suppressor proteins interactions Zusammenfassung Current applications and recent advances in genomics and proteomicsGenomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding.Topics discussed include:* Qualitative knowledge models* Interpreting micro-array data* Gene regulation bioinformatics* Methods to analyze micro-array* Cancer behavior and radiation therapy* Error-control codes and the genome* Complex life science multi-database queries* Computational protein analysis* Tumor and tumor suppressor proteins interactions Inhaltsverzeichnis Preface. Contributors. 1. Qualitative Knowledge Models in Functional Genomics and Proteomics (Mor Peleg, Irene S. Gabashvili, and Russ B. Altman). 1.1. Introduction. 1.2. Methods and Tools. 1.3. Modeling Approach and Results. 1.4. Discussion. 1.5. Conclusion. References. 2. Interpreting Microarray Data and Related Applications Using Nonlinear System Identification (Michael Korenberg). 2.1. Introduction. 2.2. Background. 2.3. Parallel Cascade Identification. 2.4. Constructing Class Predictors. 2.5. Prediction Based on Gene Expression Profiling. 2.6. Comparing Different Predictors Over the Same Data Set. 2.7. Concluding Remarks. References. 3. Gene Regulation Bioinformatics of Microarray Data (Gert Thijs, Frank De Smet, Yves Moreau, Kathleen Marchal, and Bart De Moor). 3.1. Introduction. 3.2. Introduction to Transcriptional Regulation. 3.3. Measuring Gene Expression Profiles. 3.4. Preprocessing of Data. 3.5. Clustering of Gene Expression Profiles. 3.6. Cluster Validation. 3.7. Searching for Common Binding Sites of Coregulated Genes. 3.8. Inclusive: Online Integrated Analysis of Microarray Data. 3.9. Further Integrativ...
