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This book critically reviews both clinical and immunological aspects of auto- mune disease with a strong emphasis on multiple sclerosis (MS). Research in MS is one of the fastest-developing areas in modern medicine. It employs some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. It is an area in which research findings are being actively translated into treatment strategies. Advances in this area have both clinical and scientific implications for other autoimmune conditions that share many similarities with MS. The book, which comprises 24 chapters contributed by experts and thought leaders in the field, is designed to provide new insights into two arenas: our current understanding of autoimmune mechanisms and immune regulation and the latest developments in immunotherapy. This book is intended for both researchers and clinicians. Its purpose is not only to provide a comprehensive review on the recent advances in the two arenas m- tioned above but also to reflect the current opinions or concepts that influence our thinking about the disease mechanisms and our way of treating MS patients. Many of these issues have emerged from recent studies and are somewhat contradictory to traditional thinking. For example, recent studies have indicated that MS is more heterogeneous in many aspects than traditionally thought. Pathologically, in ad- tion to demyelination and inflammation, there is axonal loss or damage detectable in the central nervous system (CNS) lesions.
List of contents
Immune Regulation and Autoimmune Disease.- Autoimmune Response and Immune Tolerance.- Priming Regulatory T Cells and Antigen-Specific Suppression of Autoimmune Disease.- Peripheral T Cell Regulation and Autoimmunity.- Anti-Ergotypic Regulation of the Immune Response.- How B Cells Contribute to Multiple Sclerosis Pathology.- Molecular Basis for Induction of Tolerance in Type I Diabetes.- Co-stimulation Regulation of Immune Tolerance and Autoimmunity.- Invariant NKT Cells and Immune Regulation in Multiple Sclerosis.- CD4+CD25+ Regulatory T Cells in Autoimmune Disease.- Immunopathogenesis of Multiple Sclerosis: Overview.- Viral Infection and Multiple Sclerosis.- Multiple Sclerosis Pathology During Early and Late Disease Phases: Pathogenic and Clinical Relevance.- CD8+ T Cells in Multiple Sclerosis.- Novel Immunotherapeutic Strategies and Emerging Treatments.- Review of Novel Immunotherapeutic Strategies for MS.- T Cell Vaccination in Autoimmune Disease.- Trivalent T Cell Receptor Peptide Vaccine for Treatment of Multiple Sclerosis Targets Predominant V Genes Widely Implicated in Autoimmune Diseases and Allergy.- Nonmyeloablative Stem Cell Transplantation for Multiple Sclerosis.- T Cell-Targeted Therapy for Rheumatoid Arthritis.- Estrogens in the Treatment of Multiple Sclerosis.- Immune Regeneration Through Hematopoietic Stem Cell Transplantation to Restore Tolerance in Autoimmune Disease.- Cell Transplantation of Peripherally Derived Adult Cells for Promoting Recovery from CNS Injury.- Multiple Sclerosis: Future Directions and Prospects.
Summary
This book critically reviews both clinical and immunological aspects of auto- mune disease with a strong emphasis on multiple sclerosis (MS). Research in MS is one of the fastest-developing areas in modern medicine. It employs some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. It is an area in which research findings are being actively translated into treatment strategies. Advances in this area have both clinical and scientific implications for other autoimmune conditions that share many similarities with MS. The book, which comprises 24 chapters contributed by experts and thought leaders in the field, is designed to provide new insights into two arenas: our current understanding of autoimmune mechanisms and immune regulation and the latest developments in immunotherapy. This book is intended for both researchers and clinicians. Its purpose is not only to provide a comprehensive review on the recent advances in the two arenas m- tioned above but also to reflect the current opinions or concepts that influence our thinking about the disease mechanisms and our way of treating MS patients. Many of these issues have emerged from recent studies and are somewhat contradictory to traditional thinking. For example, recent studies have indicated that MS is more heterogeneous in many aspects than traditionally thought. Pathologically, in ad- tion to demyelination and inflammation, there is axonal loss or damage detectable in the central nervous system (CNS) lesions.
