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Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states.
List of contents
Structure and Function of Gastrointestinal Endocrine Cells.- 1 Biosynthesis and Processing of Gastrointestinal Peptide Hormones.- 2 Mechanisms That Attenuate Signaling by Regulatory Peptides.- 3 Cellular and Molecular Targets of Gastrin.- 4 Receptors for Peptides of the VIP/PACAP and PYY/NPY/PP Families.- 5 Cholecystokinin: Hormonal and Neurocrine Regulator of Postprandial Gastrointestinal Function.- 6 Effects of Aging on Gut Hormones.- 7 Gastrointestinal Hormones and Gastrointestinal Cancer Growth.- 8 Intraluminal Regulatory Peptides and Intestinal Cholecystokinin Secretion.- 9 Neuroendocrine Control of the Exocrine Pancreas.- 10 Neuroendocrine Immune Axis in the Intestine.- 11 Neuroendocrine Regulation of Intestinal Peristalsis.- 12 Pancreatic Polypeptide and Glucose Metabolism.- 13 Peptide Release from the Upper Small Intestine.- 14 Regulation of Gastric Acid Secretion.- 15 Role of Cholecystokinin in Physiologic and Pathophysiologic Growth of the Pancreas.- 16 Expression of the Neurotensin/Neuromedin N Gene in the Gut: A Potential Model for Gut Differentiation.- 17 Glucose-Dependent Insulinotropic Polypeptide (GIP): Incretin vs Enterogastrone.- 18 Insulin-Like Growth Factors and Their Receptors and Binding Proteins in the Gastrointestinal System.- 19 Intestinal Proglucagon-Derived Peptides.- 20 Islet Amyloid Polypeptide and Adrenomedullin: Novel Peptide Hormones Expressed in the Gastro-EnteroPancreatic Region.- 21 Peptide YY.
Summary
Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract.
Report
"... the book contains a wealth of material...The authors are experts in the field, and they have done a thorough job in covering their topics...This book is an excellent reference on gut hormones..."-The Quarterly Review of Biology
