Harnessing Nanozymes to Combat Antimicrobial Resistance

This book spotlights the potential of nanozymes in combating antimicrobial resistance (AMR), a growing global health crisis with high mortality and morbidity. Despite progress in understanding AMR, current therapies often fall short. Nanozymes, a novel class of enzyme-mimicking nanomaterials, offer diverse applications to address AMR and related infections. By enhancing targeted drug delivery, nanozyme-based treatments improve efficacy while reducing adverse effects, highlighting their potential to overcome the limitations of existing therapies.
AMR, driven by the overuse and misuse of antibiotics, is an escalating global challenge that results in resistant bacterial strains and significant health burdens. Current treatments lack optimal efficacy, emphasizing the need for innovative approaches. Nanozymes, with their enzyme-like catalytic activities at the nanoscale, present a promising solution to the complexities of AMR and associated infections.
Nanozymes offer a significant advantage in antimicrobial resistance (AMR) management by enhancing the efficacy of treatments. These formulations can navigate biological barriers with precision, improving drug bioavailability and minimizing off-target effects. Additionally, nanozymes facilitate early disease detection through advanced nano-imaging techniques, allowing the identification of infections and resistant bacteria at early stages-crucial for timely interventions. They can also carry anti-inflammatory agents, providing targeted relief and reducing systemic side effects.
In summary, nanozymes are a transformative tool in AMR management, addressing the limitations of current therapies. By improving drug delivery, enabling early detection, and offering precision therapeutics, nanozymes enhance treatment effectiveness while minimizing adverse effects. Their versatility opens avenues for personalized treatment regimens, paving the way for innovative, tailored healthcare solutions that can better meet the challenges of AMR, ultimately improving patient outcomes and public health.
This book targets scientists and researchers in AMR, drug delivery, and nanomaterials, covering AMR fundamentals to advanced nanozyme applications. It offers detailed, up-to-date insights, serving as a vital resource for students, clinicians, academics, and industry professionals across various scientific disciplines.

List of contents

Chapter 1. Introduction to Antimicrobial Resistance (AMR).- Chapter 2. Fundamentals of Nanozymes.- Chapter 3. Mechanisms of Antimicrobial Action.- Chapter 4. Nanozyme Synthesis and Functionalization.- Chapter 5. Nanozymes in Bacterial Infections.- Chapter 6. Nanozymes in Viral Infections.- Chapter 7. Nanozymes in Fungal and Parasitic Infections.- Chapter 8. Safety and Toxicity of Nanozymes.- Chapter 9. Nanozyme Delivery Systems.- Chapter 10. Nanozymes in Combination Therapies.- Chapter 11. Regulatory and Ethical Considerations.- Chapter 12. Future Perspectives and Challenges.

About the author

Dr. Anurag Kumar Singh
 is currently working as a Research Associate (ICMR-RA) in the Department of Pharmaceutical Engineering and Technology at the Indian Institute of Technology (Banaras Hindu University), Varanasi, India. Previously, he served as a Postdoctoral Research Assistant in Cancer Biology at the Department of Biological Sciences, Alabama State University, USA, and at the Institute of Nanotechnology & Advanced Materials, Department of Chemistry, Bar-Ilan University, Israel. He brings over 3.5 years of postdoctoral research experience to his current role. Dr. Singh earned his doctoral degree in pharmaceutical chemistry from the Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, and his M. Pharm degree from the School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, India. His research focuses on the development of innovative nano-particulate systems for applications in chronic pain management, neurodegenerative disorders, and brain-targeted drug delivery. This includes expertise in dendrimers, nanoporous silica/silicon materials, and polymeric nanoparticles for controlled drug delivery, diagnostics, and nanotheranostics. Dr. Singh’s work aims to integrate engineering, pharmaceutical, and medical sciences to advance nanomedicine for healthcare and biomedical applications. Dr. Singh has an impressive academic record with over 50 research articles, reviews, and journal editorials published in esteemed national and international journals. He has edited or authored more than eight books and contributed over 15 book chapters published by internationally renowned presses.

Dr. Rajesh Kuma
r is working as Associate Professor at Maharaja Agrasen School of Pharmacy, Maharaja Agrasen University, Solan, Himachal Pradesh. He worked as junior and senior research fellow in the Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi and has very good experimental hands on bioanalytical techniques viz. sample preparation, extraction of drug molecules from bioanalytical samples, chromatographic separations and interpretation by HPLC, GC-MS and also has an experience of 3 years for conducting Therapeutic Drug Monitoring (TDM) of different drug molecules. Dr. Kumar worked as Bioanalytical Research Associate (LC-MS/MS Department) in Micro Therapeutic Research Labs Private Limited (USFDA, WHO, ANVISA Approved lab.) Chennai and also worked as Trainee Analyst in Arbro Pharmaceutical Limited (Analytical Division) New Delhi in LC/MS/MS Department (NABL Accredited, Government Approved Test House) for one year. He has published several research papers, including reviews, journal editorials, and book chapters in various peer-reviewed National and International journals. During the research, he has also got UGC-BHU JRF Research Fellowship Award 2016-17, National Fellowship, JRF& SRF (NFSC Award) 2017-18 by UGC and ICMR (Indian Council of Medical Research) SRF Award 2018.

Dr Vivek K. Chaturvedi
(MRSC) is a Young-Scientist Fellow (Department of Health Research, Ministry of Health and Family Welfare) at Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. Before joining the laboratory as a Young Scientist Fellow, he worked as a Postdoctoral research associate at the Department of Gastroenterology, IMSBHU, Varanasi. He earned his PhD degree in Biotechnology from University of Allahabad (a central university), Prayagraj, India. He received his BSc degree in Biological Sciences and MSc degree in Biochemistry from Veer Bahadur Singh Purvanchal University, Jaunpur, India. Dr Chaturvedi’s research interests include the synthesis and functionalization of nano-biomaterials as well as their fabrication for the development of various biosensors that may be useful for the early detection and treatment of cancer and gastrointestinal diseases. Besides these, he has published many original articles in peer-reviewed high-impact journals along with many internationally edited and authored books.

Dr. Virat Khanna
is serving as Associate Dean, Research and Development, Chandigarh University, Punjab, India. He is an accomplished academic and researcher with over 15 years of experience in higher education and scientific research. He has authored more than 80 publications in high-impact, peer-reviewed journals indexed in SCI, Scopus, and Web of Science. His research contributions span nanotechnology, materials science, and sustainable development. He has served as an editor for multiple books and conference proceedings with leading international publishers, including Springer, CRC Press, IGI Global, and Bentham Science. He is actively involved in scholarly publishing and currently serves on the Editorial Board of Scientific Reports (Nature Group) and Discover Nano (Springer). Additionally, he holds the position of Academic Editor for the Journal of Nanotechnology published by Wiley. Dr Khanna is also the Book Series Editor for Recent Advances in Materials for Nanotechnology, published by CRC Press (Taylor & Francis).

Summary

This book spotlights the potential of nanozymes in combating antimicrobial resistance (AMR), a growing global health crisis with high mortality and morbidity. Despite progress in understanding AMR, current therapies often fall short. Nanozymes, a novel class of enzyme-mimicking nanomaterials, offer diverse applications to address AMR and related infections. By enhancing targeted drug delivery, nanozyme-based treatments improve efficacy while reducing adverse effects, highlighting their potential to overcome the limitations of existing therapies.
AMR, driven by the overuse and misuse of antibiotics, is an escalating global challenge that results in resistant bacterial strains and significant health burdens. Current treatments lack optimal efficacy, emphasizing the need for innovative approaches. Nanozymes, with their enzyme-like catalytic activities at the nanoscale, present a promising solution to the complexities of AMR and associated infections.
Nanozymes offer a significant advantage in antimicrobial resistance (AMR) management by enhancing the efficacy of treatments. These formulations can navigate biological barriers with precision, improving drug bioavailability and minimizing off-target effects. Additionally, nanozymes facilitate early disease detection through advanced nano-imaging techniques, allowing the identification of infections and resistant bacteria at early stages-crucial for timely interventions. They can also carry anti-inflammatory agents, providing targeted relief and reducing systemic side effects.
In summary, nanozymes are a transformative tool in AMR management, addressing the limitations of current therapies. By improving drug delivery, enabling early detection, and offering precision therapeutics, nanozymes enhance treatment effectiveness while minimizing adverse effects. Their versatility opens avenues for personalized treatment regimens, paving the way for innovative, tailored healthcare solutions that can better meet the challenges of AMR, ultimately improving patient outcomes and public health.
This book targets scientists and researchers in AMR, drug delivery, and nanomaterials, covering AMR fundamentals to advanced nanozyme applications. It offers detailed, up-to-date insights, serving as a vital resource for students, clinicians, academics, and industry professionals across various scientific disciplines.

Product details

• Assisted by: Vivek K. Chaturvedi (Editor), Vivek K Chaturvedi et al (Editor), Virat Khanna (Editor), Rajesh Kumar (Editor), Anurag Kumar Singh (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Release: 04.04.2026
• EAN: 9783032165398
• ISBN: 978-3-0-3216539-8
• Illustrations: Approx. 430 p.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Nanotechnologie, Umwelt, Biochemie, Medizinische Chemie, Pharmazeutische Chemie, Mikrobiologie (nicht-medizinisch), biochemistry, microbiology, Nanotechnology, Environmental Sciences, Biomedical Research, Pharmaceutics, antimicrobial resistance, drug delivery, Nanozymes, Fungal and Parasitic Infections