Navigating Tuberculosis - Insights into Host-Pathogen Protein Interactions

Navigating Tuberculosis: Insights into Host-Pathogen Protein Interactions explores the intricate interactions between host proteins and the tuberculosis pathogen, Mycobacterium tuberculosis (M. tb), emphasizing their roles in virulence and pathogenesis. This comprehensive volume aims to advance knowledge and strategies to combat tuberculosis, aligning with the World Health Organization's goal of eradicating TB by 2035. The book delves into the mechanistic insights of host and TB pathogen proteins, focusing on their roles in modulating innate and adaptive immunity. It enhances the understanding of TB pathomechanisms by elucidating the interplay between host defenses and M. tb infection, providing a foundation for developing targeted strategies to mitigate tuberculosis. Key regulatory pathways and protein factors involved in host-pathogen interactions are explored, informing the design and implementation of innovative approaches to combat TB effectively. This book addresses the need for up-to-date information on host-pathogen interactions in tuberculosis, incorporating the latest research findings and advancements. It highlights emerging therapeutic targets among host and TB pathogen proteins and integrates multidisciplinary approaches from microbiology, immunology, and molecular biology, offering a holistic perspective on TB pathophysiology. Researchers will find detailed discussions on key host proteins involved in tuberculosis pathogenesis, the molecular tactics employed by M. tb to subvert host defenses, and host-mediated inhibition strategies targeting M. tb. The book provides a comprehensive framework for understanding M. tb pathophysiology and disease-causing mechanisms, laying the groundwork for proposing new host-directed therapies and host-pathogen interface-targeting therapies. This volume in the series Foundations and Frontiers in Enzymology is an essential resource for basic research scientists and researchers in microbiology, immunology, molecular biology, and infectious diseases. It equips them with the knowledge necessary to design better mitigation strategies against tuberculosis, fostering interdisciplinary collaborations and advancing the field of TB research.

List of contents

1. Mechanisms of Mycobacterium tuberculosis Virulence: The esx1 Locus and Host Countermeasures
2. Host Adaptation Strategies of Mycobacterium tuberculosis: A Molecular Perspective
3. Unravelling M. tuberculosis Manipulation of Host Immunity: Insights from Functional Genomics and Proteomics
4. Macrophages: Frontline Warriors Against Mycobacterium tuberculosis Invasion
5. Unravelling Mycobacterium tuberculosis Pathogenesis: Insights into PE/PPE Proteins from a Molecular Viewpoint
6. Host-Pathogen Dynamics in Mycobacterium tuberculosis: The Impact of PE/PPE Proteins on Innate and Adaptive Immunity
7. PE/PPE Proteins in Mycobacterium tuberculosis: Key Regulators of Apoptosis and Pathogenic Outcomes
8. Autophagy and Mycobacterium tuberculosis: Host Defense Mechanisms Versus Pathogen Evasion
9. Mechanisms of Phagosomal Damage Detection and Response to Mycobacterium tuberculosis: Repair, Autophagy, and Biogenesis
10. Programmed Cell Death During Mycobacterium tuberculosis Infection: The Roles of Pyroptosis and Necroptosis in Host Defense
11. Metabolic Repurposing in Mycobacterium-Infected Macrophages: A Strategy for Enhanced Virulence and Survival
12. Type I Interferons in Tuberculosis: Friend or Foe?
13. Type II Interferon in Tuberculosis: Orchestrating Infection Outcome through Mechanistic Insights
14. Cell Envelope Dynamics in Mycobacterium tuberculosis: Implications for Tuberculosis Pathogenesis and Host-Pathogen Interaction
15. Combatting Tuberculosis Drug Resistance: Effective Strategies for Overcoming Challenges
16. Beyond Treatment: Strategies for Mitigating Long-Term Morbidity and Mortality in Tuberculosis Survivors

About the author

Dr. Mohd Shariq, Ph.D., obtained his doctoral degree in Biological Sciences from Jawaharlal Nehru University, India, focusing on Cellular and Molecular Biology of Infectious Diseases. He has authored 30 peer-reviewed articles in prestigious journals like Autophagy, Journal of Medical Virology, European Respiratory Review, and Frontiers in Immunology. Dr. Shariq has mentored numerous students in independent research projects and is joining GITAM University, Hyderabad, as an Assistant Professor, bringing extensive expertise in Cellular and Molecular Biology and Microbiology. Previously, as a Senior Scientist and Group Leader at QuantLase Imaging Laboratory, he published four research articles in reputed international journals such as Cellular and Molecular Biology Letters (Springer). His research on host-pathogen interactions in tuberculosis and the role of M. tb proteins in inflammation and autophagy regulation has significantly advanced the understanding of TB pathomechanisms. Additionally, his insights into drug resistance mechanisms in Candida albicans and Helicobacter pylori infections have enriched our understanding of microbial pathogenesis. Dr. Shariq serves as an acting reviewer for esteemed journals like Frontiers, Scientific Reports, and others, and acts as a review editor for Gut Pathogens and Frontiers.Professor Seyed E. Hasnain is a distinguished figure in tuberculosis research, specializing in infection biology and functional epidemiology. His groundbreaking contributions have earned him international recognition and a multitude of prestigious awards, including the Robert Koch Fellowship in Berlin, Membership of the American Academy of Microbiology, and induction into the German National Academy of Sciences-Leopoldina. He is also a Fellow of TWAS (Italy) and all major Indian Science Academies (FNA/FASc/FNASc). Prof. Hasnain's accolades further include the Alexander von Humboldt Research Award, the Shanti Swarup Bhatnagar Prize, the GD Birla Award, and the JC Bose Fellowship. With a distinguished career spanning decades, Prof. Hasnain has served in various esteemed roles. Notably, he was a member of the Science Advisory Council to the Prime Minister of India for two terms (2004-2014), the inaugural Director of the Centre for DNA Fingerprinting and Diagnostics in Hyderabad, and subsequently the Vice-Chancellor of the University of Hyderabad from 2005 to 2011, and the Vice-Chancellor of Jamia Hamdard University (2016-2021). He also held the esteemed position of invited Prof. at IIT-Delhi from 2011 to 2019. Presently, Prof. Hasnain serves as a National Science Chair at the Indian Institute of Technology, Delhi (IIT-D), and is also a Distinguished Professor at Sharda University.Professor Nasreen Z. Ehtesham completed her Master's degree at Aligarh Muslim University, Aligarh, and pursued graduate training at the University of Alberta, Edmonton, Canada. She earned her Ph.D. from the National Institute of Immunology, New Delhi, in 1991, followed by a Rockefeller Postdoc Fellowship at the ICGEB. As Deputy Director at the National Institute of Nutrition, Hyderabad, her research group focused on nutrition and inflammation biology, particularly in elucidating the link between pathogenesis, inflammation, and stress response using the Mycobacterium tuberculosis infection model. Prof. Nasreen Ehtesham has contributed extensively to decision-making bodies of the Health Ministry and S&T Ministry and has published over 100 research papers in esteemed journals like PNAS, garnering over 5000 citations. She served as Director-in-Charge at the ICMR National Institute of Pathology, New Delhi, and is recognized as an Elected Fellow of the Indian National Science Academy, the National Academy of Sciences, India, and the Andhra Pradesh Akademi of Sciences, India. She has received numerous awards, including the ICMR Kshanika Award in 2014 and the Outstanding Work of the Year Award from NII, New Delhi, in 1990. Prof. Nasreen Ehtesham is a member of various professional societies and serves on the editorial boards of several esteemed journals, including Molecular and Cellular Biochemistry (Springer) and Gut Pathogens (BioMed Central). Presently, Prof. Nasreen Ehtesham is a Distinguished Professors at Sharda University.

Product details

• Assisted by: Seyed Ehtesham Hasnain (Editor), Nasreen Zafar Ehtesham (Editor), Mohammad Shariq (Editor)
• Publisher: Elsevier
• Languages: English
• Product format: Paperback / Softback
• Release: 20.06.2026
• EAN: 9780443277351
• ISBN: 978-0-443-27735-1
• Weight: 450 g
• Series: Foundations and Frontiers in Enzymology
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; MEDICAL / Infectious Diseases, SCIENCE / Life Sciences / Microbiology, MEDICAL / Chemotherapy, Infectious & contagious diseases, Infectious and contagious diseases, Chemotherapy / Pharmacotherapy