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"Recent Therapeutic Targets for the Prevention and Management of Diabetic Complications: Neuropathy" covers recent research and therapeutic approaches of this diabetic complication for the management of diabetes. It is a detailed reference to understand the pathogenesis of diabetes to alleviate the overall complications of neuropathy to improve patient care. It is uniquely focused on the different aspects of neuropathy with a focus on the molecular and biological pathways (therapeutic target) to detect an early diagnosis to better manage the disease and improve patient care. The book is useful to anyone in the field particularly those who do research investigations, and day-to-day practice in the area of diabetes.
List of contents
1. Diagnosis, prognosis, and molecular mechanisms behind the development of diabetic neuropathy
2. Detection and grading of diabetic neuropathy using skin biopsies and corneal confocal microscopy
3. Pathogenesis and novel therapeutic approaches of diabetic neuropathy in Retina
4. Nrf2 as a potential therapeutic target for diabetic nephropathy
5. Roles of exercise and weight loss in the management of diabetic neuropathy
6. Roles of tricyclic antidepressants, serotonin or adrenaline (norepinephrine) reuptake inhibitors and gabapentin analogues for treating diabetic neuropathy
7. Pain management in diabetic neuropathy. What are the challenges?
8. Lipids as a therapeutic target in diabetic neuropathy
9. Roles of microRNAs in diabetic neuropathy
10. Roles of lidocaine, capsaicin, clonidine, amitriptyline, and ketamine in the management of diabetic neuropathic pain
11. Gene Therapy. A novel therapeutic target for the management of diabetic neuropathy
12. Inflammation. A therapeutic target for diabetic neuropathy
13. Matrix metalloproteinases as a potential therapeutic target for diabetic neuropathic pain
14. Heme oxygenase 1 as a novel target for the treatment of diabetic peripheral neuropathy
15. Voltage gated sodium channel as a therapeutic target for the painful diabetic neuropathy
16. Endoplasmic Reticulum Stress as a target for the treatment of peripheral diabetic neuropathy
17. Sirtuins and Nrf2 as SIRT1 activators as emerging treatments for diabetic neuropathy
18. mTOR signalling pathway as a potential mechanism and therapeutic target for diabetic small fiber neuropathy
19. Polyphenols and phenolic acids as therapeutic approach for the management of diabetic neuropathy
20. Alpha Lipoic acid as a therapeutic approach for the treatment of diabetic peripheral neuropathy
About the author
Dr. Shahidul Islam, MD, Professor, PhD, Department of Biochemistry, University of KwaZulu-Natal. He is an expert in diabetes and has achieved a number of awards including the International Endocrine Society. He has over 30 years of research and teaching experience, has published in 20 international peer reviewed journals, is an “Editor-in-Chief” of the “World Journal of Diabetes”. Prof. Islam has been selected as one of the Global Top 2% researcher by Mandeley during 2019 and as one of the Global Top 0.016% researcher in the area of Experimental Diabetes Mellitus by Expert Escape during 2021. Prof. Islam has published 14 peer reviewed book chapters, more than 200 research articles in the international peer reviewed journals including 11 reviews since 2004. He has successfully supervised the research projects of over 45 Postdoctoral Fellows and students.
