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This open-access book presents recent advances in our understanding of the nano-structure of synaptic junctions in terms of their organization, mechanisms of assembly, and role in neuronal signaling as well as plasticity. Traditionally, a single synapse was assumed to have a homogeneous organization of molecular components both at the active zone and postsynaptically. Recent advances in imaging tools and the further elucidation of the physiological significance of distinct forms of release have challenged this notion. This is a timely book that will richly contribute to the ongoing efforts to develop this novel perspective into the study of the nervous system.
List of contents
Nano-organization of the synapse: An Overview.- Structural Biology of Neurotransmitter Release Machinery.- Vesicle pools: Composition, physical locations.- Organization of the active zone.- Synaptic cell adhesion.- Synaptic cell adhesion, a structural perspective.- Postsynaptic receptors and scaffolds.- Functional nano-segregation of distinct forms of neurotransmission.- Optical approaches to dissect nano-structure.- Cryo-EM tomography.- Roles of Glia in Synapse Nano-Organization.
About the author
Dr. Kavalali was born and raised in Istanbul, Turkey. He studied Electrical Engineering at Boğaziçi University in Istanbul. In 1995, he received his Ph.D. degree in Biomedical Engineering from Rutgers University. In 1999, he completed his postdoctoral studies at Stanford University in the Department of Molecular and Cellular Physiology. He then joined the faculty at the Center for Basic Neuroscience at UT Southwestern Medical Center at Dallas where he rose to the rank of Professor in the Departments of Neuroscience and Physiology. He also held the Rosewood Corporation Chair, in addition to serving as the Chair of the Neuroscience Graduate Program between 2008 and 2016. In 2018, Dr. Kavalali joined the Department of Pharmacology at Vanderbilt University as a Professor and the William Stokes Chair in Experimental Therapeutics. He currently serves as the Chair of the Department.
Summary
This open-access book presents recent advances in our understanding of the nano-structure of synaptic junctions in terms of their organization, mechanisms of assembly, and role in neuronal signaling as well as plasticity. Traditionally, a single synapse was assumed to have a homogeneous organization of molecular components both at the active zone and postsynaptically. Recent advances in imaging tools and the further elucidation of the physiological significance of distinct forms of release have challenged this notion. This is a timely book that will richly contribute to the ongoing efforts to develop this novel perspective into the study of the nervous system.
