Heart Failure II - A Comprehensive Guide to Pathophysiology and Clinical Care

This new and thoroughly updated textbook and its companion volume elucidates the etiology of heart failure (HF) to assist understanding of the clinical therapies and surgery available. They explain these in light of the better understanding of the pathophysiology of HF, which has translated into dramatic improvements in patient outcome.
 
The chapters detail the causes, diagnosis and treatment of HF, recognizing that having become the leading cause of morbidity, mortality and hospitalization in the developed world, even patients with the most advanced HF have options that allow prolonged survival. This includes alternatives to cardiac transplantation, including mechanical circulatory support with a rapidly growing number of new, smaller, more reliable devices becoming available. 
 
Heart Failure II: A Comprehensive Guide to Pathophysiology and Clinical Care remains an important reference for all involved in the management of these patients and provides a scientific and clinical resource for trainees in cardiovascular disease as well as physicians involved in caring for these patients.

List of contents

Patient Selection for Cardiac Transplantation.- Pathophysiology of the Alloimmune Response and Immunosuppression.- Antibody-Mediated Rejection.- Infections After Cardiac Transplantation.- Post-transplant Complications: Hypertension, Renal Dysfunction, Diabetes Mellitus, Malignancy, Arrhythmias, Osteoporosis, Sexual Dysfunction.- Biomarkers and Cardiac Transplantation.- Patient Selection for Durable Mechanical Circulatory Support.- Acute Mechanical Circulatory Support.- Mechanical Circulatory Support as a Bridge to Heart Transplantation.- Medical Management of the Patient with Chronic Mechanical Circulatory Support.- The Total Artificial Heart.- Xenotransplantation.- The Role of the Advanced Practice Provider in the Management of Patients with Heart Failure.- Physiology of Stem Cells.- Stem Cell Therapy in Heart Failure.- Gene Therapy for Heart Failure.- Origins of Quality Metrics.- Exercise and Patients with Heart Failure and Reduced Ejection Fraction.- Heart Failure Management and Development of Heart Failure Programs.- Inflammation & heart failure.- Cancer Treatments, Cardiovascular Disease, and Cardiac Tumors.

About the author

Howard J Eisen is Director of Research at the Jefferson Heart Institute and Professor of Medicine at Thomas Jefferson University.
Dr. Howard J. Eisen, MD received his undergraduate AB degree in Biochemistry cum laude, with distinction in all subjects and Phi Beta Kappa in 1977 from the Cornell University College of Arts and Sciences in Ithaca, New York. He then went to the University of Pennsylvania School of Medicine in Philadelphia, Pennsylvania where he received his MD degree in 1981. He was elected to the Alpha Omega Alpha Medical Honor Society. Dr. Eisen did his internal medicine residency at the Hospital of the University of Pennsylvania in Philadelphia from 1981-84. He the received his Cardiology training at the Washington University School of Medicine and Barnes Hospital in St. Louis, Missouri from 1984-87. He the joined the faculty of the Cardiology Division at the University of Pennsylvania as Director of Nuclear Cardiology, Medical Co-Director of the Cardiac Transplant Program and Assistant Professor of Medicine and Radiology from 1987-1993. In 1993, Dr. Eisen became the Medical Director of the Advanced Heart Failure and Cardiac Transplant Programs at Temple University School of Medicine in Philadelphia, Pennsylvania and Professor of Medicine and Physiology.
At Temple. Dr. Eisen led the largest cardiac transplant program in the United States and was a leader of the everolinus clinical trial published in the New England Journal of Medicine and he was in leadership positions for the Neoral, MMF, Myfortic and photopheresis cardiac transplant clinical trials and the CARGO I study. In 2005, Dr. Eisen was recruited to become Chief of the Cardiology Division at the Drexel University College of Medicine and Hahnemann University Hospital in Philadelphia, Pennsylvania.
He was the Joseph DiPalma MD Family Professor of Cardiology and Thomas J. Vischer professor of Medicine at the Drexel University College of Medicine. He led the everolimus-versus MMF clinical trial, the largest clinical trial in cardiac transplant patients. Dr. Eisen continues to be active in research in heart failure, cardiac transplantation and mechanical circulatory support and continues to care for these patients.
He is an Associate Editor of the American Journal of Transplantation and Transplantation, is a Deputy Editor of Clinical Transplantation, a Senior Editorial Consultant of the Journal of Heart and Lung Transplantation and a member of the Editorial Board of JACC-Heart Failure and the Journal of Cardiac Failure. He has been named to Board of Directors of the ISHLT. Dr. Eisen has been a grant Reviewer for the NIH, National Heart Lung and Blood Institute and American Heart Association. He has been named a Top Doctor by Castle-Connolly and a Best Doctor in the US and a Top Doctor by Philadelphia Magazine
He is also one of 27 top Cardiologists on Forbes Honor Role of Cardiologists and the only one in Pennsylvania. He was recently elected a member of the Association of University Cardiologists. He is presently Professor of Medicine (tenured) and Medical Director of the Cardiac Transplant, MCS and Advanced Heart Failure Programs and Diagnostic Cardiology at the Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center.
 

Summary

This new and thoroughly updated textbook and its companion volume elucidates the etiology of heart failure (HF) to assist understanding of the clinical therapies and surgery available. They explain these in light of the better understanding of the pathophysiology of HF, which has translated into dramatic improvements in patient outcome.
 
The chapters detail the causes, diagnosis and treatment of HF, recognizing that having become the leading cause of morbidity, mortality and hospitalization in the developed world, even patients with the most advanced HF have options that allow prolonged survival. This includes alternatives to cardiac transplantation, including mechanical circulatory support with a rapidly growing number of new, smaller, more reliable devices becoming available. 
 
Heart Failure II: A Comprehensive Guide to Pathophysiology and Clinical Care remains an important reference for all involved in the management of these patients and provides a scientific and clinical resource for trainees in cardiovascular disease as well as physicians involved in caring for these patients.

Product details

• Assisted by: Howard Eisen (Editor)
• Publisher: Springer International Publishing
• Languages: English, German
• Product format: Hardback
• Release: 18.02.2026
• EAN: 9783032126283
• ISBN: 978-3-032-12628-3
• Illustrations: Approx. 500 p. 40 illus. With online files/update., schwarz-weiss Illustrationen
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Cardiology, heart failure, Cardiovascular Disease, mechanical circulatory support, Cardiac Resynchronization Therapy, Cardiac Transplantation