Multiple Drug Resistance in Cancer - Cellular, Molecular and Clinical Approaches

This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the mdr genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione- S-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.

Summary

Covers a wide range of topics relating to the cellular and molecular biology, as well as clinical aspects, of the problem of multiple drug resistance in cancer. Specific mechanisms discussed in detail include P-Glycoprotein and other drug transport proteins; and Topoisomerases I and II.

Product details

• Assisted by: Manfred Clynes (Editor), Martin Clynes (Editor)
• Publisher: Springer Netherlands
• Languages: English
• Product format: Hardback
• Released: 28.02.1994
• EAN: 9780792326694
• ISBN: 978-0-7923-2669-4
• No. of pages: 393
• Weight: 1156 g
• Illustrations: VIII, 393 p.
• Subject: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine