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A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery. Highlights include RNA-based therapies for many diseases, up-to-date methods and applications, and insight into the enormous potential to provide a new generation of drugs.
List of contents
Antisense Therapeutics.- Antisense Inhibition.- Cardiovascular.- Local Application of Antisense for Prevention of Restenosis.- Antisense Therapeutics for Hypertension.- Antisense Strategies for the Treatment of Heart Failure.- Cancer.- Clinical Studies of Antisense Oligonucleotides for Cancer Therapy.- Antisense Therapy in Clinical Oncology.- Radionuclide-Peptide Nucleic Acid in Diagnosis and Treatment of Pancreatic Cancer.- uppression of Pancreatic and Colon Cancer Cells by Antisense K-ras RNA Expression Vectors.- Induction of Tumor Cell Apoptosis and Chemosensitization by Antisense Strategies.- Utility of Antioncogene Ribozymes and Antisense Oligonucleotides in Reversing Drug Resistance.- Blood-Brain Barrier.- Transport of Antisense Across the Blood-Brain Barrier.- Dermal.- Transdermal Delivery of Antisense Oligonucletoides.- Drugs.- Antisense Strategies for Redirection of Drug Metabolism.- Gastrointestinal.- Antisense Oligonucleotide Treatment of Inflammatory Bowel Diseases.- Hepatitis.- Optimizing Electroporation Conditions for Intracellular Delivery of Morpholino Antisense Oligonucleotides Directed Against the Hepatitis C Virus Internal Ribosome Entry Site.
Summary
A timely primer on the new reality of antisense and RNA inhibition for treating a broad range of diseases. The authors show how antisense oligonucleotides are being designed and studied in relation to hypertension, various cancers, inflammatory bowel disease, brain disorders, the blood-brain barrier, and drug delivery.
Additional text
From Reviews of the First Edition...
"...strongly recommended both to scientists already engaged in antisense research and to newcomers alike." -Trends in Biotechnology
"...enables an appreciation of the exciting possibilities this field offers for the development of new uniquely selective therapeutic agents via precisely designed inhibitors of the expression of disease associated genes." -Journal of Medicinal Chemistry
Reviews from the Second Edition...
"This book does an excellent job of showing the reader that antisense oligonucletoids could be valuable therapeutic drugs in the future." - Doody's Health Sciences Book
Report
From Reviews of the First Edition...
"...strongly recommended both to scientists already engaged in antisense research and to newcomers alike." -Trends in Biotechnology
"...enables an appreciation of the exciting possibilities this field offers for the development of new uniquely selective therapeutic agents via precisely designed inhibitors of the expression of disease associated genes." -Journal of Medicinal Chemistry
Reviews from the Second Edition...
"This book does an excellent job of showing the reader that antisense oligonucletoids could be valuable therapeutic drugs in the future." - Doody's Health Sciences Book
