Medicinal Organometallic Chemistry

Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler's solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes - Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide - an essential signaling molecule.

List of contents

Arsenic-Based Drugs: From Fowler's Solution to Modern Anticancer Chemotherapy.- Activation Mechanisms for Organometallic Anticancer Complexes.- Organometallic Antitumour Agents with Alternative Modes of Action.- Ferrocene Functionalized Endocrine Modulators as Anticancer Agents.- Titanocenes: Cytotoxic and Anti-angiogenic Chemotherapy Against Advanced Renal-Cell Cancer.- Organometallics as Structural Scaffolds for Enzyme Inhibitor Design.- Bioorganometallic Chemistry and Malaria.- Biomedical Applications of Organometal-Peptide Conjugates.- Organometallic Radiopharmaceuticals.- Carbon Monoxide: An Essential Signalling Molecule.

Report

From the reviews:
"Edited by Gèrard Jaouen and Nils Metzler-Nolte, this book describes recent advances in the design, synthesis, mechanistic understanding and medical application of organometallic compounds. ... Overall this is an informative book and will be welcomed by those working in the field of inorganic medicinal chemistry." (Simon P. Fricker, Platinum Metals Reviews, Vol. 55 (4), October, 2011)

Product details

• Assisted by: Gérard Jaouen (Editor), Nils Metzler-Nolte (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 05.11.2012
• EAN: 9783642264979
• ISBN: 978-3-642-26497-9
• No. of pages: 294
• Dimensions: 174 mm x 235 mm x 17 mm
• Weight: 476 g
• Illustrations: XVIII, 294 p. 179 illus., 11 illus. in color.
• Series: Topics in Organometallic Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Biotechnologie, Onkologie, C, Medizinische Chemie, Pharmazeutische Chemie, ORGANOMETALLIC CHEMISTRY, biochemistry, Oncology, Chemistry and Materials Science, Cancer Research, Biomedical Research, Industrial chemistry & chemical engineering, Pharmaceutical technology, Pharmaceutics, Pharmaceutical Sciences/Technology, MEDICINAL CHEMISTRY, Bioprocess Engineering, Biochemical Engineering, Chemical Bioengineering