Calcium Antagonists - Pharmacology and Clinical Research

Although the importance of calcium (Ca2+) in the maintenance of cardiac contractility was recognized as early as 1880, the critical role of the ion in the contractile process in skeletal, cardiac, and smooth muscle has only been established within the last three decades.
As the complexity of the pharmacological actions of the Ca2+ channel inhibitors grows, there is a continued need to further clarify the inhibitors, both chemically and functionally.
This volume provides an update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the growing area of molecular biology of Ca2+ channels. In the cardiovascular area, in addition to the well-established clinical uses of Ca2+ channel inhibitors, exciting new work pointing to an application in atherosclerosis is described. The book also includes important uses of Ca2+ antagonists in novel areas of interest such as the gastrointestinal tract, renal protection and multi-drug resistance.

List of contents

I: Calcium Channels, the Molecular Approach. II: Cardiovascular Applications of Calcium Antagonists: from Pathophysiology to Therapy. A: Hypertension and Heart Failure. B: Atherosclerosis. III: Calcium Channels and Calcium Antagonists in Neurobiology and Nervous Disorders. IV: Novel Applications and Aspects of Calcium Antagonist Pharmacology. A: Gastrointestinal Tract. B: Renal Protection. C: Multidrug Resistance. Index.

Summary

An update of the field based on the work presented at the 5th International Symposium on Calcium Antagonists: Pharmacology and Clinical Research. It reviews the current state of the molecular biology of Ca2+ channels in the cardiovascular area, and an application in atherosclerosis is described.

Product details

• Authors: International Symposium on Calcium Antagonists
• Assisted by: Etc. (Editor), T. Godfraind (Editor), S. Govoni (Editor), R. (Institute of Pharmacological Sciences Paoletti (Editor), Rodolfo Paoletti (Editor), P.M. (Center for Experimental Therapeutics Vanhoutte (Editor), Paul M Vanhoutte (Editor), Paul M. Vanhoutte (Editor)
• Publisher: Springer Netherlands
• Languages: English
• Product format: Hardback
• Released: 31.05.1993
• EAN: 9780792322597
• ISBN: 978-0-7923-2259-7
• No. of pages: 381
• Weight: 725 g
• Illustrations: Illustr.
• Series: Medical Science Symposia Series; Medical Science Symposia
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine