Nicotine and Related Alkaloids - Absorption, distribution, metabolism and excretion

This is an essential reference volume for anyone interested in nicotine and tobacco. An international team of authors contribute to this comprehensive review of current knowledge of the pharmacokinetics and metabolism of nicotine.

List of contents

Plant metabolism. Mammalian metabolism: overview. Nicotine to cotinine. Nicotine to cotinine: enzyme induction. N-oxidation, N-methylation and conjugation reactions. Nicotine metabolism: beyond cotinine. Extrahepatic nicotine metabolism. Minor tobacco alkaloids. Pharmacokinetics of nicotine and metabolites in animals. Pharmacokinetics of nicotine and metabolites in humans. Factors influencing individual variation in nicotine pharmacokinetics. Analysis of nicotine. Chromatographic analysis of nicotine and metabolites. Nicotine and metabolites: pharmacokinetics models. New methods for probing the in vivo disposition of nicotine in humans. Aspects of metabolism of S- nicotine.

Summary

Brings together previously diffuse material on nicotine and its related alkaloids, and places this material in the context of the latest research in the field. The text places particular emphasis on mammalian systems, although examples from plants are included.

Product details

• Authors: John Wahren
• Assisted by: J W Gorrod (Editor), J. W. Gorrod (Editor), J. Wahren (Editor), John Wahren (Editor)
• Publisher: Springer Netherlands
• Languages: English
• Product format: Hardback
• Released: 01.09.1993
• EAN: 9780412557408
• ISBN: 978-0-412-55740-8
• No. of pages: 299
• Weight: 560 g
• Illustrations: XVII, 299 p.
• Subject: Natural sciences, medicine, IT, technology > Medicine > Pharmacy