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Informationen zum Autor Lutz Edler is the editor of Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment, published by Wiley. Christos Kitsos is the editor of Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment, published by Wiley. Klappentext Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendium of state-of-the-art methods proposed and used, featuring contributions from eminent authors with varied experience from academia, government, and industry. Provides a comprehensive summary of currently available quantitative methods for risk assessment of both cancer and non-cancer problems. Describes the applications and the limitations of current mathematical modelling and statistical analysis methods (classical and Bayesian). Includes an extensive introduction and discussion to each chapter. Features detailed studies of risk assessments using biologically-based modelling approaches. Discusses the varying computational aspects of the methods proposed. Provides a global perspective on human health risk assessment by featuring case studies from a wide range of countries. Features an extensive bibliography with links to relevant background information within each chapter. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment will appeal to researchers and practitioners in public health & epidemiology, and postgraduate students alike. It will also be of interest to professionals working in risk assessment agencies. Zusammenfassung Research into quantitative methods in cancer and human health risk assessment continues to grow! and the methodology is now used widely in practice. This book brings together the current state-of-the-art in mathematical! statistical and computational methods in cancer and human health risk assessment! with a focus on practical implementation. Inhaltsverzeichnis Contributors. Preface. Introduction. I CANCER AND HUMAN HEALTH RISK ASSESSMENT. Introductory remarks. 1. Principles of Cancer Risk Assessment: The Risk Assessment Paradigm (Vincent J. Cogliano). 1.1 The risk assessment paradigm. 1.2 Hazard identification. 1.3 Dose-response assessment. II BIOLOGICAL ASPECTS OF CARCINOGENESIS. Introductory remarks. 2. Molecular Epidemiology in Cancer Research (Gerassimos Voutsinas, Anastasia Apostolidou and Natalia Spyrou). 2.1 Introduction. 2.2 From carcinogen exposure to cancer. 2.3 Biomarkers. 2.4 Validation of biomarkers. 2.5 Factors influencing cancer risk. 2.6 New tools in molecular epidemiology. 2.7 Conclusions. 3. Genetic Polymorphisms in Metabolising Enzymes as Lung Cancer Risk Factors (Angela Risch, Heike Dally and Lutz Edler). 3.1 Introduction. 3.2 Methodological aspects. 3.3 Examples. 3.4 Discussion. Acknowledgements. 4. Biological Carcinogenesis: Theories and Models (Sylvia Solakidi, Constantinos E. Vorgias and Constantine E. Sekeris). 4.1 Introduction. 4.2 Models of human carcinogenesis. 4.3 The multistage mouse skin carcinogenesis model. 4.4 Epilogue. 5. Biological and Mathematical Aspects of Multistage Carcinogenesis (E. Georg Luebeck and Sur...
