In Vivo Reprogramming in Regenerative Medicine

This new volume reviews current progress on different approaches of in vivo reprogramming technology. Leaders in the field discuss how in vivo cell lineage reprogramming can be used for tissue repair and regeneration in different organs, including brain, spinal cord, pancreas, liver and heart. Recent studies on in vivo cell reprogramming towards pluripotency are reviewed; examples are given to show its potential in regenerative medicine. In each chapter, the regenerative potential of different in vivo reprogramming approaches is discussed in detail. More specifically, how different tissue failures or damages can be treated with this technology is explained. Examples from various animal models are given and the regenerative potential of in vivo reprogramming is compared to that of cell transplantation studies. The last chapter discusses current challenges of these preclinical studies and gives suggestions in order to improve the current strategies. Future directions are indicated for the transition of in vivo reprogramming technology to clinical settings. This is among the first books in the literature which specifically focuses on the in vivo reprogramming technology in regenerative medicine and these chapters collectively cover one of the most important and exciting topics of regenerative medicine.

List of contents

Chapter 1. Introduction to in vivo cell Reprogramming Technology.- Chapter 2. In vivo Reprogramming for Regenerating Insulin-Secreting Cells.- Chapter 3. Direct Reprogramming to Beta Cells.- Chapter 4. In vivo Lineage Reprogramming of Fibroblasts to Cardiomyocytes for Heart Regeneration.- Chapter 5: In vivo cell Reprogramming for Long-term Pluripotency.- Chapter 6: In vivo Transient Reprogramming Towards Pluripotency for Tissue Repair and Regeneration.- Chapter 7. Challenges and Future Perspectives for in vivo Reprogramming Technology.

Product details

• Assisted by: Açelya Yilmazer (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.12.2017
• EAN: 9783319657196
• ISBN: 978-3-31-965719-6
• No. of pages: 103
• Dimensions: 161 mm x 12 mm x 242 mm
• Weight: 303 g
• Illustrations: XVII, 103 p. 15 illus. in color.
• Series: Stem Cell Biology and Regenerative Medicine
• Subjects: Natural sciences, medicine, IT, technology > Biology > Genetics, genetic engineering; B, Surgery, regenerative medicine, Tissue Engineering, Biomedical and Life Sciences, Transplant Surgery, Cellular biology (cytology), Regenerative Medicine and Tissue Engineering, Regenerative Medicine/Tissue Engineering, Surgical transplantation, Cell Biology, Genetics (non-medical), Stem Cell Biology, stem cells, Scientific equipment, experiments and techniques, Cell Culture