Chalcones - From Drug Discovery to Pharmaceutical Applications

Chalcones: From Drug Discovery to Pharmaceutical Applications offers an exploration of chalcones, organic compounds renowned for their versatile chemistry and significance in drug research. This detailed reference discusses the natural sources of chalcones, their extraction and synthesis techniques, and their importance in developing innovative pharmaceuticals. Both newcomers and seasoned professionals will find foundational insights, methodologies for structural characterization, and the growing role these compounds play in advancing therapeutic solutions for a wide range of medical conditions. This resource stands out for its critical guidance on drug development strategies and its broad overview of chalcones’ potential to address complex health challenges.

The book is divided into three comprehensive sections: "Foundations of Chalcones Research," which examines chalcone origins and laboratory methods; "Pharmacology of Chalcones," detailing their pharmacokinetics, safety profiles, and unique medicinal properties, including antiviral, antibacterial, anticancer, and neuroprotective effects; and "Prospects," focusing on drug formulation, chalcone-based clinical trials, and future pharmaceutical applications.

List of contents

Part I - Foundations of Chalcones research
1. Natural sources of Chalcones
2. Extraction methods from traditional to green approaches
3. Structural and spectroscopic characterization of Chalcones
4. Synthesis, structural modifications and scale-up methods
5. Medicinal Chemistry Strategies in the Chalcone scaffold
6. Chalcones as versatile intermediates in organic chemistry
7. Chalcones in metal complexes

Part II - Pharmacology of Chalcones
8. PK properties and bioavailability of Chalcones
9. Chalcone Toxicity
10. Natural Chalcones in Traditional Medicine
11. Chalcones as Antiviral Agents
12. Chalcones as Antibacterial and Antitubercular Agents
13. Anticancer Potential of Chalcones
14. Chalcones as Neuroprotective and Anti-Alzheimer’s Disease Agents
15. Chalcones as Antiprotozoal, Antiparasitic and Insecticidal Agents
16. Chalcones as Antifungal Agents
17. Chalcones as Anti-inflammatory, Anti-ulcer and Antioxidant Agents
18. Chalcones as Anti-hyperlipidemic, Anti-diabetic and Insulin Regulating Agents

Part III - Prospects
19. Chalcone-containing Products (food supplements, nutraceuticals, functional food)
20. Formulations and Drug Delivery of Chalcones
21. Chalcone-protein co-crystals in the PDB
22. Clinical Trials of Chalcone-based drug candidates

About the author

Dr. Carradori is a very prolific researcher with papers dealing with both synthetic and natural products characterized by promising biological activities. Regarding this topic, he has been involved in the study of HAT inhibitors, hCA IX and XII inhibitors, kinesin Eg5 inhibitors and natural compounds active in the field of oncology. Recently, he has been focusing on “drug repurposing” disclosing a patent on new roles played by antiparasitic benzimidazoles as anti-cancer agents. He also was Co-Guest Editor of several special issues, co-author of chapters for two books (one edited by Elsevier) and acts as Editorial Board member of several peer-reviewed journals.Dr. Moi Davide is a researcher involved in the design, synthesis, and characterization of small molecules endowed with promising biological activity. He is mainly involved in the study of compounds with multitarget activity in the cancer field, as well as in the study of epigenetic modulators, such as HDACs and Carbonic Anhydrase modulators. In the last years, he has been involved in the synthesis of high-value scaffolds through photo- and organo-catalysis, as well as in the development of fluorescent molecules for bio-imaging. He is also the author of several research articles and, Guest and Co-Guest editor of different special issues.
Dr. Ilaria D’Agostino is a medicinal chemist involved in the development of small molecules as putative anticancer, antifibrotic, and antiinfective agents and hybrid compounds for a multitarget approach. Currently, she is mainly involved in the design and synthesis of compounds targeting cancer stem cells for an antitumoral application along with innovative targeted theranostic agents for precision medicine. She is the author of several research articles and book chapters, and Co-Guest editor of different special issues.

Product details

• Assisted by: Simone Carradori (Editor), Ilaria D’Agostino (Editor), Davide Moi (Editor)
• Publisher: Elsevier
• Languages: English
• Product format: Paperback / Softback
• Release: 01.04.2026
• EAN: 9780443438127
• ISBN: 978-0-443-43812-7
• Weight: 450 g
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; MEDICAL / Pharmacology, Pharmacology