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Informationen zum Autor Johann Schaller and Simon Gerber are the authors of Human Blood Plasma Proteins: Structure and Function, published by Wiley. Klappentext Human plasma contains the most comprehensive version of the human proteome. The complexity of the 'plasma proteome' is quickly understood when one considers all the various forms of blood plasma proteins present in plasma: precursor and mature forms, splice variants, degradation products and of course all combinations of posttranslational modifications.Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include:* Introduction to blood components and blood plasma proteins* Blood plasma protein domains, motifs and repeats* Blood plasma protein families and posttranslational modifications* Blood coagulation and fibrinolysis* The complement system* The immune system* Enzymes* Inhibitors* Lipoproteins* Hormones* Cytokines and growth factors* Transport and storageThe information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure.Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine. Zusammenfassung The first textbook on blood plasma proteins published for ten years, this book gives an overview of human blood plasma proteins with special emphasis on their structure and function and, if known, also in relation to pathological states and diseases. Inhaltsverzeichnis Preface xi 1 Introduction 1 References 3 Part I 5 2 Blood Components 7 2.1 Introduction 7 2.2 Short History 7 2.3 Blood Components 8 2.3.1 Blood cells 8 2.3.2 Blood plasma 12 2.3.3 The blood group system 13 References 15 Data Sheet 16 3 Blood Plasma Proteins 17 3.1 Introduction 17 3.2 Short History 17 3.3 Classification of Blood Plasma Proteins 17 References 20 Part II 21 4 Domains, Motifs and Repeats 23 4.1 Introduction 23 4.2 The Epidermal Growth Factor (EGF)-Like Domain 24 4.3 The Kringle Domain 26 4.4 The g-Carboxyglutamic Acid-Rich (Gla) Domain 27 4.5 The PAN/Apple Domain 28 4.6 The Sushi/CCP/SCR Domain 30 4.7 The Fibronectin Type I, the Fibronectin Type II Collagen-Binding and the Fibronectin Type III Domains 31 4.8 The Coagulation Factors 5/8 Type C Domain (FA58C) 32 4.9 The Thrombospondin Type I Repeat (TSP1) 34 4.10 The VWFA, VWFC and VWFD Domains 35 4.11 The Cystatin-Like Domain 36 4.12 The LDL-Receptor Class A (LDLRA) and Class B (LDLRB) Domains 36 4.13 The C-Terminal Cystine Knot (CTCK) Structure 38 4.14 The Anaphylatoxin Domain 40 4.15 The CUB Domain 40 4.16 The NTR Domain 41 4.17 The C-Type Lectin (CTL) Domain 42 4.18 The Ig-Like Domain 43 References 44 5 Protein Families 47 5.1 Introduction 47 5.2 Serine Proteases: The Trypsin Family 47 5.3 Serine Protease Inhibitors (Serpins) 48 5.4 The a2-Macroglobulin Family 50 5.5 The Serum Albumin Family 52 5.6 The Pancreatic Trypsin Inhibitor (Kunitz) Family Signature 52 5.7 The Kazal Serine Protease Inhibitors Family Signature 53 5.8 The Multicopper Oxidase Family 54 5.9 The Lipocalin Family 54 5.10 The Globin Family 55 5.11 The Glucagon/Gastric Inhibitory Polypeptide (GIP)/Sec...
