Oncocytic (Hürthle Cell) Thyroid Lesions - From Diagnosis to Treatment

This book provides a comprehensive overview of oncocytic (Hürthle cell) lesions, whether neoplastic or non-neoplastic, with a view to clarifying some uncertainties and helping clinicians reach an accurate diagnosis and choose the best therapeutic options.
Many recent studies have highlighted important facts relevant to oncocytic (Hürthle cell) lesions and have proposed several clinical and non-clinical tools that may help in diagnosis and management. Recent molecular studies have shed light on the distinct oncogenic features of oncocytic/Hürthle cell carcinomas, suggesting that they represent a separate pathological entity from both oncocytic/Hürthle cell adenomas and follicular cell carcinomas. However, only a few facts are established, while challenges and debates still encompass most of the spectrum of oncocytic (Hürthle cell) lesions.
The volume discusses a wide range of topics, including controversies in nomenclature, origin, and cytology/histology of oncocytic (Hürthle) cells, as well as controversies in oncocytic cell lesion pathogenesis, biological and clinical behavior, diagnosis, and management.
Regarding oncocytic (Hürthle cell) neoplasms, this book discusses controversies in pathological classification, clinical presentation, diagnostic work-up, and therapeutic strategies. A special chapter addresses updates in genetic and molecular diagnostics of oncocytic (Hürthle cell) carcinoma.
Finally, this book includes a chapter summarizing the recent international guidelines and recommendations related to oncocytic lesions, particularly carcinoma, thus aiding in decision-making and appropriate management.
This book is meant for all specialists entrusted with the care of patients suffering from oncocytic thyroid lesions: head and neck surgeons, maxillofacial surgeons, endocrine surgeons, endocrinologists, oncologists, and otolaryngologists.

List of contents

1. Embryology and Developmental Disorders.- 2. Oncocytic (Hurthle) Cells in Thyroid Disorders.- 3. Oncocytic (Hurthle Cell) Lesions: Controversy of Nomenclature, Origin, and Histology.- 4. Oncocytic (Hurthle Cell) Lesions: Controversy of Pathogenesis, Biology and Clinical Behavior.- 5. Oncocytic (Hurtle Cell) Lesions:  Controversy of Oncocytic (Hurthle) Cells in Cytology .- 6. Oncocytic (Hurthle Cell) Lesions: Controversy of Diagnosis Neoplastic or Non-neoplastic.- 7. Oncocytic (Hurthle Cell) Lesions: Controversy of Management.- 8. Oncocytic (Hurthle Cell) Neoplasm: Controversy of Pathological Classification.- 9. Oncocytic (Hurthle Cell) Neoplasm: Controversy of Nature - Benign or Malignant?.- 10. Oncocytic (Hurthle Cell) Neoplasm: Controversy of Clinical Behavior.- 11. Oncocytic (Hurthle Cell) Adenoma: Controversy of Diagnosis and Treatment.- 12. Oncocytic (Hurthle Cell) Carcinoma: Controversy of Pathophysiology, Diagnosis and Treatment.- 13. Oncocytic (Hurthle Cell) Carcinoma: Updates in Genetic and Molecular Diagnostics .- 14. Oncocytic (Hurthle Cell) Carcinoma: Guidelines and Decision-Making.- 15. Oncocytic (Hurthle Cell) Carcinoma: Controversy of Prognosis.- 16. Oncocytic (Hurthle Cell) Lesions: Conclusions.

About the author

Prof. Mahmoud Fathi Sakr is a professor of Surgery, 
Head and Neck and Endocrine Surgery Unit
 at the Faculty of Medicine, Alexandria University, Egypt. He graduated in 1981 and earned his MS and PhD in Surgery at Alexandria University, Egypt. He completed his fellowship at the University of Pittsburgh, Pennsylvania, USA. He is a fellow of the International College of Surgeons (ICS) and the American College of Surgeons (ACS). His main fields of interest are 
head and neck
 and endocrine surgery. Dr. Sakr has published 32 national books and 14 international books, including six published by Springer. He has also published 5 “Patient Information Series”, a “Manual for Clinical Practice”, and 118 scientific articles in esteemed journals. He serves on the editorial board of many international journals.

Summary

This book provides a comprehensive overview of oncocytic (
Hürthle
 cell) lesions, whether neoplastic or non-neoplastic, with a view to clarifying some uncertainties and helping clinicians reach an accurate diagnosis and choose the best therapeutic options.


Many recent studies have highlighted important facts relevant to oncocytic (
Hürthle
 cell) lesions and have proposed several clinical and non-clinical tools that may help in diagnosis and management. Recent molecular studies have shed light on the distinct oncogenic features of oncocytic/
Hürthle
 cell carcinomas, suggesting that they represent a separate pathological entity from both oncocytic/
Hürthle
 cell adenomas and follicular cell carcinomas. However, only a few facts are established, while challenges and debates still encompass most of the spectrum of oncocytic (
Hürthle
 cell) lesions.


The volume discusses a wide range of topics, including controversies 
in
 nomenclature, origin, and cytology/histology of oncocytic (
Hürthle
) cells, as well as controversies 
in
 oncocytic cell lesion pathogenesis, biological and clinical behavior, diagnosis, and management.


Regarding oncocytic (
Hürthle
 cell) neoplasms, this book discusses controversies 
in
 pathological classification, clinical presentation, diagnostic work-up, and therapeutic strategies. A special chapter addresses updates in genetic and molecular diagnostics of oncocytic (
Hürthle
 cell) carcinoma.


Finally, this book includes a chapter summarizing the recent international guidelines and recommendations related to oncocytic lesions, particularly carcinoma, thus aiding in decision-making and appropriate management.


This book is meant for all specialists entrusted with the care of patients suffering from oncocytic thyroid lesions: head and neck surgeons, maxillofacial surgeons, endocrine surgeons, endocrinologists, oncologists, and otolaryngologists.

Product details

• Authors: Mahmoud Sakr
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 25.10.2025
• EAN: 9783032031143
• ISBN: 978-3-0-3203114-3
• No. of pages: 259
• Illustrations: XV, 259 p. 56 illus., 47 illus. in color.
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Onkologie, Endokrinologie, Otorhinolaryngology, THYROID GLAND, Mund-, Kiefer- und Gesichtschirurgie, Endocrinology, molecular biology, Oncology, ORAL AND MAXILLOFACIAL SURGERY, mitochondria, Eosinophilic cytoplasm, Adenoma, Oxyphil / Askanazy cells, Follicular carcinoma