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Klappentext Aimed at the basic scientist or clinician scientist teaching a course or conducting research in the basic science underlying the major neurological diseases, this book provides cutting-edge research on the fundamental mechanisms, including molecular, responsible for these diseases. The major categories of neurological disease have been covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book includes approximately 20 topics, each divided into several individual chapters that are exemplary of the topical area. The topics include the major categories of disease, including metabolic, neurodegenerative, genetic, neuroimmunological, cerebrovascular, paroxysmal, neoplastic, infectious, and developmental. There are also sections on motor neuron diseases, peripheral neuropathies, myopathies, autonomic disorders, pain, sleep disorders, substance abuse, neurological disturbances associated with medical diseases, and techniques for imaging the nervous system. The chapters are written by acknowledged experts in their fields, and each contains appropriate tables, illustrations and references. Zusammenfassung Aimed at basic scientists or clinician scientists teaching a course or conducting research on the basic science underlying the major neurological diseases! this book provides an overview of research on the fundamental disorders of the nervous system! including physiological and molecular aspects of dysfunction. Inhaltsverzeichnis Part I. Central Nervous System Section A. Metabolic Diseases - Hugo W. Moser Chapter 1: Leukodystrophies Chapter 2: Lysosomal Disorders of the Nervous System Chapter 3: The Neurobiology of Peroxisomal Disorders Chapter 4: Creatine Deficiency Syndromes Section B. Neurodegenerative Disorders - Gregor Wenning Chapter 5: Parkinson's Disease Chapter 6: Alzheimer Disease Chapter 7: Multiple System Atrophy Chapter 8: Olivopontocerebellar Atrophy (OPCA) Chapter 9: Neurobiology of Progressive Supranuclear Palsy Section C. Genetic Diseases - Christopher Gomez Chapter 10: Protein Aggregation Disorders Chapter 11: RNA-Based Disorders of Muscle and Brain Chapter 12: Ion Channel Disorders Chapter 13: Spinocerebellar Ataxia Type 1 Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical Hypoxia Section D. Neuroimmunological Disorders - Anthony T. Reder Chapter 15: Paraneoplastic Neurological Disorders Chapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Future Chapter 17: Progressive Multifocal Leukoencephalopathy Chapter 18: Multiple Sclerosis Chapter 19: Immune-Mediated Neuropathies Chapter 20: Hashimoto Encephalopathy Section E. Cerebrovascular Diseases - Lewis Morgenstern Chapter 21: Vascular Cognitive Impairment Chapter 22: Cardioembolism Chapter 23: Coagulation Disorders Chapter 24: Clinical and Neurobiological Aspects of Stroke Recovery Chapter 25: Non-Atherosclerotic Cerebral Vasculopathies Chapter 26: Subarachnoid Hemorrhage Chapter 27: Cerebral Ischemia: Molecular Mechanisms and Protective Therapies Chapter 28: Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain Injury Section F. Paroxysmal Disorders - Timothy A. Pedley Chapter 29: Idiopathic Epilepsies Chapter 30: Paroxysmal Dyskinesia Chapter 31: Neurobiology of Myoclonus Chapter 32: Channelopathies of the Nervous System Chapter 33: Migraine Chapter 34: Temporal Lobe Epilepsy Section G. Neoplastic Diseases - John Laterra Chapter 35: CNS Metastases Robert J. Weil Chapter 36: Meningioma Katrin Lamszus, Christian Hagel, and Manfred Westphal Chapte...
