Complex Carbohydrates in Health and Disease

This book provides latest insights into the clinical significance of glycans, new glycan-based therapeutics and vaccines and enriches understanding of the significant role that glycans play in the etiology and for the course of inborn and acquired diseases. It outlines why proper glycosylation is a key factor for the design and the manufacturing of therapeutic antibodies and other therapeutic glycoproteins.

List of contents

Part I Synthesis of Complex Carbohydrates and Carbohydrate-based Drugs.- Chemical Synthesis of Complex Carbohydrates.- Synthesis of Sulfated Carbohydrates Glycosaminoglycans.- Activity-Based Profiling of Retaining Glycosidases in Disease Diagnosis and Their Application in Drug Discovery.- Part II Analytical Methods of Complex Carbohydrates.- Advanced Mass Spectrometry Techniques for the Characterization of Carbohydrates.- The Road Toward Nanopore Sequencing of Glycosaminoglycans.- Decrypting Glycosaminglycan Sulfation Code with Computational Approaches.- Part III Biological Functions & Medical Relevance.- Glycosylation in Stem Cell Biology.- Role of Antibody Glycosylation in Health, Disease and Therapy.- Diagnostic and Therapeutic Approaches in Congenital Disorders of Glycosylation.- Glycosylation in Cancer.

Summary

Outlines why proper glycosylation is a key factor for the design and the manufacturing of therapeutic antibodies and other therapeutic glycoproteins

Product details

• Assisted by: Kevin Pagel (Editor), Fabian Pfrengle (Editor), Rudolf Tauber (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Release: 28.12.2025
• EAN: 9783032025821
• ISBN: 978-3-0-3202582-1
• No. of pages: 400
• Illustrations: Approx. 400 p. 100 illus., 30 illus. in color.
• Series: Handbook of Experimental Pharmacology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Medizinische Chemie, Pharmazeutische Chemie, immune system, Pharmacology, infectious diseases, MEDICINAL CHEMISTRY, Biomarker, Rare Diseases, heparinase, ion mobility mass spectrometry, glycosylation, oligosaccarides, O-glycans, glycosaminoglycans, glycoengineering, N-glycans, glycosyltransferases, LGG, selectins, glycomimetics, MALDI-TOF, lectins, sialic acid, glycomics