Complex Carbohydrates in Health and Disease

List of contents

Part I Synthesis of Complex Carbohydrates and Carbohydrate-based Drugs.- Chemical Synthesis of Complex Carbohydrates.- Synthesis of Sulfated Carbohydrates Glycosaminoglycans.- Activity-Based Profiling of Retaining Glycosidases in Disease Diagnosis and Their Application in Drug Discovery.- Part II Analytical Methods of Complex Carbohydrates.- Advanced Mass Spectrometry Techniques for the Characterization of Carbohydrates.- The Road Toward Nanopore Sequencing of Glycosaminoglycans.- Decrypting Glycosaminglycan Sulfation Code with Computational Approaches.- Part III Biological Functions & Medical Relevance.- Glycosylation in Stem Cell Biology.- Role of Antibody Glycosylation in Health, Disease and Therapy.- Diagnostic and Therapeutic Approaches in Congenital Disorders of Glycosylation.- Glycosylation in Cancer.

Summary

Outlines why proper glycosylation is a key factor for the design and the manufacturing of therapeutic antibodies and other therapeutic glycoproteins

Product details

• Assisted by: Kevin Pagel (Editor), Fabian Pfrengle (Editor), Rudolf Tauber (Editor)
• Publisher: Springer International Publishing
• Languages: English
• Product format: Hardback
• Release: 28.12.2025
• EAN: 9783032025821
• ISBN: 978-3-032-02582-1
• Illustrations: Approx. 400 p. 100 illus., 30 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen
• Series: Handbook of Experimental Pharmacology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Medizinische Chemie, Pharmazeutische Chemie, immune system, Pharmacology, infectious diseases, MEDICINAL CHEMISTRY, Biomarker, Rare Diseases, heparinase, ion mobility mass spectrometry, glycosylation, oligosaccarides, O-glycans, glycosaminoglycans, glycoengineering, N-glycans, glycosyltransferases, LGG, selectins, glycomimetics, MALDI-TOF, lectins, sialic acid, glycomics