Biotechnology Engineering - A Practical Approach on Bioprocess Development from Lab to Industrial Scale

Biotechnology Engineering: A Practical Approach on Bioprocess Development from Lab to Industrial Scale offers a comprehensive guide on biotechnology engineering, focusing on transforming research and development into commercially viable industrial processes. The book addresses the needs of the market by providing structured chapters, practical methods, and real-world case studies. Readers will gain valuable insights into bioprocessing basics, scalable solutions, optimization techniques, and collaboration opportunities. The text also covers essential regulatory compliance information, bridging the gap between theoretical knowledge and practical applications.

The book is a vital resource for academics, scientists, engineers, and professionals in bioprocess development. It includes detailed discussions, calculations, and case studies, modern bioreactors, and software tools used in the industry. Serving as a desktop reference, it effectively combines theory with real-world applications to support the development of bioprocesses on all scales.

List of contents

PART A: Cell culture and Kinetic study
1. Culturing of microbial, animal and plant cells in lab scale
2. Microbial growth and cell kinetics
3. Design, optimization, and Inoculum development for culturing the cells
4. Lab scale studies on Submerged Liquid Fermentation (SLF) and Solid State Fermentation (SSF)

PART B: Bioreactor handling and operation
5. Fundamental of Bioreactors and accessories
6. Design Aspects and Aseptic Maintenance of Bioreactors
7. Cleaning Techniques for Bioreactors and Regulatory Standards
8. Bioreactor sterilization techniques and equipment
9. Standard Operating Procedures and Auditing in Bioprocess Industries
10. Operation and control of Submerged Liquid Fermenters
11. Operation and control of submerged solid fermenters
12. Equipment for downstream Product Recovery and Purification
13. Modern Reactors and Software Tools in Bioprocess Development

PART C: Bioreactor Scale up aspects and case studies
14. Scale-Up Rules and Reactor Accessories
15. Scale-Up Strategies for Submerged Liquid Fermentation
16. Scale-Up Strategies for Solid State Fermentation
17. Scale-Up Constraints from Lab Scale to Industrial Scale

PART D: Bioproducts
18. Commercial Bioproducts from Bioreactors
19. Bioproducts from Fermentation and their Economic Impact
20. Manufacturing Techniques for Bioproducts

About the author

Dr. Vinayaka B Shet is an Associate Professor in the Department of Biotechnology Engineering, NMAMIT, off-campus centre, Nitte (Deemed to be university), Nitte, Karnataka, India. He holds a Ph.D. in Biotechnology from VTU Belgavi, an M.Tech. in Industrial Biotechnology from the National Institute of Technology Karnataka (NITK), and a B.E. in Biotechnology from P.A. College of Engineering, Mangaluru. He has over 18 years of experience in Academics, 10 years in Research, and 1 year in Industry. He received a young researcher award. He has published over 30 research articles and 10 book chapters and holds two Indian patents. He is a reviewer of various journals. He serves as Coordinator (Accreditation and Compliance) at Nitte (Deemed to be University), Mangaluru, India.
Dr. Sandesh K is an Assistant Professor in the Department of Biotechnology Engineering, NMAMIT, off-campus centre, Nitte (Deemed to be university), Nitte, Karnataka, India. He holds a Ph.D. in Biotechnology from VTU Belgavi, and M.Tech. in Chemical Plant Design from the National Institute of Technology Karnataka (NITK), and B.E. in Chemical from B.M.S. College of Engineering, Bengaluru. He has over 14 years of experience in Academics and Research. He has many international and national publications in reputed journals and book chapters. He holds few Indian patents in his area of research. He is a reviewer of various journals.Dr. Nabisab Mujawar Mubarak is an Associate Professor in the Department
of Chemical Engineering, College of Engineering, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia.He is a scientific reviewer for numerous Chemical Engineering
andNanotechnology journals. In research, Dr.Mubarak has published
over 450 journal papers and 40 conference proceedings, authored 85
book chapters, and has an H-index of 87. His areas of interest include
the synthesis of carbon nanomaterials, the production of magnetic
biochar using microwaves, and wastewater treatment utilizing advanced
materials. He received the Curtin Malaysia Most Productive Research Award, the Outstanding Faculty of Chemical Engineering Award, the Best Scientific Research Award in London, and the Exceptional ScientistAward in publication and citation by
i-Proclaim, Malaysia. Since 2020, he has also been listed among the top 2% of the world’s most influential scientists in the fields of chemistry and energy. The List of the Top 2% of Scientists in
the World, compiled and published by Stanford University, is based on international scientific
publications, the number of scientific citations for research, and participation in the review and
editing of scientific research. Dr. Mubarak is a Fellow Member of the Institution of Engineers
Australia, a Chartered Professional Engineer of The Institution of Engineers Australia, and a
Chartered Chemical Engineer of the Institute of Chemical Engineering, UK. He has published
11 books and is coeditor for ongoing Elsevier-edited books: 1) Nanomaterials for Carbon
Capture and Conversion Technique, 2) Advanced Nanomaterials and Nanocomposites for Bioelectrochemical Systems, 3) Water Treatment Using Engineered Carbon Nanotubes,4)
Hybrid Nanomaterials for Sustainable Applications: Case Studies and Applications, 5), Sustainable
Nanotechnology for Environmental Remediation, 6) Nanotechnology for Biomedical
Applications,7) Nanotechnology for Electronic Applications, 8) Application of Bio-Additives
for the Food Industry, 9) Contemporary Nanomaterials inMaterial Engineering Applications,
10)Fundamentals of Biomaterials: ASupplementary Textbook, 11) EmergingWater Pollutants:
Concerns and Remediation Technologies.Rama Rao Karri is an Associate Professor in the Faculty of Engineering at Universiti Teknologi Brunei. He holds a PhD from IIT Delhi and a Master’s from IIT Kanpur in Chemical Engineering. With over 20 years of experience in academia, industry, and research, he has experience working in multidisciplinary fields and has expertise in various evolutionary optimization techniques and process modelling. His expertise extends to process modeling and simulation, focusing on optimizing chemical and environmental processes to improve efficiency and sustainability. He serves on editorial boards of several international journals and acts as a peer reviewer for numerous reputed publications. He has held editorial roles including Editor-in-Chief and Associate Editor for journals such as Scientific Reports and the International Journal of Energy and Water Resources. He is also a guest editor for special issues on nanocomposites and environmental engineering topics. Additionally, he contributes to authoring and editing books on sustainable technologies, environmental remediation, and process monitoring with leading academic publishers. He also has the distinction of being listed in the Top 2% of the world’s most influential scientists in the area of environmental sciences and chemical engineering since 2021, compiled and published by Stanford University.
Prof. Dr. Mohammad Hadi Dehghani is a full professor at the Tehran University of Medical Sciences (TUMS), School of Public Health, Department of Environmental Health Engineering, Tehran, Islamic Republic of Iran. His scientific research interests include environmental science. He is the author of various research studies published in national and international journals and conference proceedings and head of several research projects at the TUMS. He has authored 20 books, 26 book chapters and more than 270 full papers published in peer-reviewed journals. He is an editorial board member, guest editor, and reviewer in many internal and international journals and a member of several international science committees worldwide. He also has the distinction of being listed in the top 2% of the world’s most influential scientists in the area of environmental sciences. He is a supervisor and advisor for many PhD and MSc theses at the TUMS. He is currently also a member of the Iranian Association of Environmental Health (IAEH) and member of the Institute for Environmental Research (IER) at the TUMS. He is an editor for 14 edited books (English): (1) Soft Computing Techniques in Solid Waste and Wastewater Management, (2) Environmental and Health Management of Novel Coronavirus Disease (COVID-19), (3) Green Technologies for the Defluoridation of Water, (4) Pesticide Remediation Technologies From Water and Wastewater, (5) COVID-19 and Sustainable Development Goals, (6) Industrial Wastewater Treatment: Emerging Technologies for Sustainability, (7) Sustainable Materials for Sensing and Remediation of Noxious Pollutants, (8) Wastewater-Based Epidemiology for the Assessment of Human Exposure to Environmental Pollutants, (9) Water Treatment Using Engineered Carbon Nanotubes, (10) Water, the Environment and the Sustainable Development Goals, (11) Sustainable Remediation Technologies for Emerging Pollutants in Aqueous Environment, (12) Health and Environmental Effects of Ambient Air Pollution, (13) Health Effects of Indoor Air Pollution, (14) Diseases Attributed to Air Pollution.

Product details

• Assisted by: Mohammad Hadi Dehghani (Editor), Sandesh Kanthakere (Editor), Rama Rao Karri (Editor), Nabisab Mujawar Mubarak (Editor), Vinayaka B. Shet (Editor)
• Publisher: Elsevier
• Languages: English
• Product format: Paperback / Softback
• Released: 29.08.2025
• EAN: 9780443314766
• ISBN: 978-0-443-31476-6
• Weight: 450 g
• Subjects: Natural sciences, medicine, IT, technology > Technology > Chemical engineering; SCIENCE / Chemistry / Industrial & Technical, TECHNOLOGY & ENGINEERING / Chemical & Biochemical, Chemical Engineering, Biochemical Engineering, Industrial chemistry and chemical engineering