Organ System Crosstalk in Critical Illness - From Basic Pathophysiology to Clinical Management

This book describes deleterious inter-organ crosstalk and its mechanistic concepts, underlying the specific clinical aspect and focusing on medical clinical management in critical care.
Homeostasis and health of multicellular organisms with multiple organs depends on inter-organ communication. Tissue injury in one organ disturbs this homeostasis and can lead to disease in multiple organs, or multi-organ failure. Many routes of inter-organ crosstalk during homeostasis are relatively well known, but inter-organ crosstalk in disease still lacks understanding. Particularly, how tissue injury in one organ can drive injury at remote sites and trigger multi-organ failure with high mortality is poorly understood. Mechanistically, inter-organ crosstalk after tissue injury could involve soluble mediators and their target receptors, cellular mediators, in particular immune cells, as well as newly identified neuro-immune connections.
The book - addressed to healthcare providers working in intensive care units - aims to provide a comprehensive synthesis and interpretation of organ crosstalk, with a particular focus on continuing practice gaps and areas with new data, to assist clinicians in making practical, yet evidence-based decisions regarding nutrition management during the different stages of critical illness.

List of contents

Part I. General Aspects.- 1. Organ system crosstalk in critical illness.- 2. Endocrine emergencies.- 3. Immune-inflammatory mechanisms in organ crosstalk: rheumatic conditions in Intensive Care Unit.- Part II. The Central Nervous System.- 4. Neuro-immune response and brain-peripheral crosstalk: the role of the complement system.- 5. New Insights in Septic Encephalopathy.- 6. Stroke-inflammatory brain blood barrier dysfunction.- 7. Molecular Crosstalk in Traumatic Brain Injury.- 8. Melatonin and the brain-heart crosstalk.- 9. Subarachnoid hemorrhage and system crosstalk.- 10. Inflammatory mechanisms in Cardiac Arrest.- Part III. The Kidneys.- 11. Molecular mechanisms of kidney crosstalk with distant organs.- 12. Brain–Kidney Crosstalk in Acute Brain Injury: Understanding Polyuria and Augmented Renal Clearance from Pathophysiology to Clinical Practice.- 13. Kidney-gut crosstalk in acute kidney injury.- 14. Myokine mediated muscle-kidney crosstalk.- 15. Renal disease and neural circuits: brain-kidney crosstalk.- 16. Cardiorenal Syndromes: Role of Humoral Signalling Cardiorenal Syndromes: Role of Humoral Signalling.- Part IV. The Liver.- 17. Liver-kidney crosstalk: hepato-renal syndrome.- 18. Gut-liver crosstalk in sepsis-induced liver injury.- 19. Muscle-liver crosstalk and sarcopenia.- 20. The liver-organs axis in gastrointestinal and pancreatic acute injury.- Part V. The Heart.- 21. Brain-heart crosstalk: Mechanisms and clinical applications for acute brain injury.- 22. Metabolic Crosstalk in Heart Failure.- 23. Detrimental role of humoral signalling in Cardio-renal crosstalk.- 24. Molecular Imaging of Inflammatory Crosstalk Across the Cardio-renal Axis Following Acute Heart Failure.- 25. Effects of Atrial Natruretic Peptide on Inter-organ Crosstalk.- Part VI. The Lungs.- 26. Brain-lungs interactions and mechanical ventilation.- 27. Gut-liver crosstalk in sepsis-induced liver injury.- 28. Host-microbe crosstalk in the lung microenvironment.- 29. Lung cell crosstalk in obese patients with ARDS.- 30. Organ crosstalk in pulmonary hypertension.- 31. The role of Osteopontin in kidneys and respiratory failure.

About the author

Denise Battaglini is an Assistant Professor in Intensive Care at the University of Genoa in Italy. She earned her PhD in Translational Medicine from the University of Barcelona, Spain, and has completed two research fellowships—one focused on pneumonia and respiratory physiotherapy at the University of Barcelona and another in neurointensive care and pulmonary critical care (mechanical ventilation) at the Federal University of Rio de Janeiro, Brazil.
In addition, Dr. Battaglini actively participates in professional organizations, serving in representative roles for the Italian Society of Anaesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI) and the European Society of Intensive Care Medicine (ESICM). Her research interests center on pulmonary critical care, with a special emphasis on rehabilitation, physiotherapy, airways management, Acute Respiratory Distress Syndrome (ARDS), and mechanical ventilation.
Through her work, Dr. Battaglini aims to improve patient outcomes in intensive care settings by implementing evidence-based practices and fostering interdisciplinary collaboration. She is dedicated to advancing the field of intensive care medicine and enhancing the quality of care provided to critically ill patients.
Silvia De Rosa is Asst, Prof. in Anaesthesiology, Intensive Care and Pain Medicine at Centre for Medical Sciences - CISMed, University of Trento, Italy. She is also a clinical researcher in Acute Kidney Injury and Extracorporeal Organ Support in collaboration with International Renal Research Institute of Vicenza. She is a Next Committee Representative of the European Society of Intensive Care Medicine (ESICM), Regional Coordinator of “Italian Society of Anesthesia Analgesia and Intensive Care” (SIAARTI - Veneto Region) and National Coordinator of Nutrition, Metabolism and Renal Therapies of SIAARTI. Her field of interest are AcuteKidney Injury and Extracorporeal Organ Support, Brain Trauma, Nutrition and Muscle Wasting, Airways Management. Co-investigator of the International registry on Acute Renal Replacement Therapy (Global-ARRT Registry) and principal investigator.
Daniel Agustin Godoy is currently is a Senior Consultant, working in the Neurocritical Care Unit of Sanatorio Pasteur, Argentina. Past president of Latin America Brain Injury Consortium (LABIC) and neurocritical care committee of Pan American and Iberic Federation of Critical Care and Intensive Care Medicine.
Associate Researcher and Visiting Professor, Neuroscience Research Group, University of São Paulo, Brazil.
Associate Professor, Diplomate in Critical Care, Pontifical Catholic University of Chile
Associate Professor, Global AO Neuro Courses, AO Neuro Foundation, Switzerland
Visiting Professor, Critical Care Medicine, San Marcos University, Lima, Peru
Researcher and Associate Professor, Universidad del Bosque, Bogotá, Colombia
Member of the Scientific and Teaching Committee, PIC Smart Campus, Neurotraumatology Service, Vall d'Hebron Hospital, Barcelona, Spain
Professor of Neurotrauma, Global Neurosurgery Cambridge University, United Kingdom and Barrow Medical College, United States
ENLS (Emergency Neurologic Life Support) Course Instructor. Neurocritical Care Society, USA.
Neurocritical Care Support Course Director. Pan-American and Iberian Federation of Critical Medicine and Intensive Care
 
His research interests in Traumatic Brain injury, multimodal non-invasive neuromonitoring, pregnancy acute brain injury, Intracerebral haemorrhage, and other topics in Neurocritical Care reflected in his wide range of publications in various first line national and international journals. He previously published 8 books about general critical care, neurocritical care and stroke.
 

Summary

This book describes deleterious inter-organ crosstalk and its mechanistic concepts, underlying the specific clinical aspect and focusing on medical clinical management in critical care.
Homeostasis and health of multicellular organisms with multiple organs depends on inter-organ communication. Tissue injury in one organ disturbs this homeostasis and can lead to disease in multiple organs, or multi-organ failure. Many routes of inter-organ crosstalk during homeostasis are relatively well known, but inter-organ crosstalk in disease still lacks understanding. Particularly, how tissue injury in one organ can drive injury at remote sites and trigger multi-organ failure with high mortality is poorly understood. Mechanistically, inter-organ crosstalk after tissue injury could involve soluble mediators and their target receptors, cellular mediators, in particular immune cells, as well as newly identified neuro-immune connections.
The book - addressed to healthcare providers working in intensive care units - aims to provide a comprehensive synthesis and interpretation of organ crosstalk, with a particular focus on continuing practice gaps and areas with new data, to assist clinicians in making practical, yet evidence-based decisions regarding nutrition management during the different stages of critical illness.

Product details

• Assisted by: Daniel Agustin Godoy (Editor), Denise Battaglini (Editor), Silvia De Rosa (Editor), Daniel Agustin Godoy (Editor)
• Publisher: Springer International Publishing
• Languages: English
• Product format: Hardback
• Release: 18.10.2025
• EAN: 9783032010230
• ISBN: 978-3-032-01023-0
• Illustrations: Approx. 465 p. 70 illus., 60 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Neurochirurgie, Neurologie und klinische Neurophysiologie, neurosurgery, Anästhesiologie, Neurology, homeostasis, Anesthesiology, Intensive Care Medicine, clinical management, inter-organ communication, neuro-immune connection, tissue injury