Clinical Nuclear Medicine in Neurology - An Atlas of Challenging Cases

This book, in its 2nd edition, is a collection of cases with challenging diagnosis, in which nuclear medicine examinations have been particularly helpful for the clinicians to perform the final diagnosis or to follow-up the patient. The cases selected are primarily in patients with neurodegenerative disorders, epilepsy and brain tumors. Authors have been selected from internationally recognized experts in the field of Neuroimaging in neurology. All authors have large experience as clinicians and as teachers within the Nuclear Medicine community.
The volume includes cases related to emerging topics such as theranostics for brain tumors and new emerging scenarios for brain PET imaging in the era of Alzheimer’s disease modifying drugs.
The book is intended for nuclear medicine specialists as well as clinicians to provide guidance in the interpretation of neurology cases in the clinical settings, particularly with regards to correct approach to the interpretation of diagnostic imaging procedures.

List of contents

Section I. Nuclear Medicine Cases of Dementia and Movement Disorders.- 1. Case 1: Mild Cognitive Impairment (MCI)—[18F]FDG and Amyloid PET.- 2. Case 2: Alzheimer’s Disease—[18F]FDG, Tau, and Amyloid PET.- 3. Case 3: Alzheimer’s Disease— Behavioral Variant.- 4. Case 4: Differentiating AD from non-AD pathology with molecular imaging (FDG, Amyloid and Tau PET).- 5. Case 5: Double plot Twist in a patient with a suspected diagnosis of Alzheimer's Disease.- 6. Case 6: FDG and amyloid PET in Limbic-predominant age-related encephalopathy.- 7. Case 7: Typical AD with Discordant Biomarkers.- 8. Case 8: Imaging Biomarkers in right temporal variant of Frontotemporal dementia.- 9. Case 9: Frontotemporal Dementia, Behavioural Variant, Mimicker.- 10. Case 10: Creutzfeldt–Jakob Disease.- 11. Case 11: Creutzfeldt–Jakob Disease with Pathological Confirmation.- 12. Case 12: Atypical Upper Motor Neuron Disease.- Section II. Nuclear Medicine Cases of Movement Disorders.- 13. Case 13: Parkinson’s Disease with Onset as Mild Cognitive Impairment (MCI).- 14. Case 14: Parkinson’s Disease with Vascular Abnormalities.- 15. Case 15: Parkinson’s Disease with Left-Sided Spasticity.- 16. Case 16: Holmes Tremor.- 17. Case 17: Multiple System Atrophy with DAT SPECT and [18F]FDG PET.- 18. Case 18: Progressive Supranuclear Palsy: Richardson Syndrome and Parkinsonian Variants.- 19. Case 19: Progressive Supranuclear Palsy (PSP).- 20. Case 20: Corticobasal Syndrome: [18F]FDG and Amyloid PET.- 21. Case 21: Huntington’s Disease with Atypical Onset.- 22. Case 22: Huntington’s Disease with Psychiatric Onset.- Section III. Nuclear Medicine Cases of Epilepsy and Encephalitis.- 23. Case 23: Non-lesional Temporal Epilepsy.- 24. Case 24: Non-Lesional Epilepsy: A Tricky Case.- 25. Case 25: Ictal [18F]FDG PET Imaging.- 26. Case 26: Focal Refractory Epilepsy with Negative MRI.- 27. Case 27: Metabolic Abnormalities After Failed Resective Temporal Epilepsy Surgery.- 28. Case 28: Hypothalamic Hamartoma with Cortical Metabolic Abnormalities.- 29. Case 29: Autoimmune Encephalitis with Unusual Antibodies.- 30. Case 30: Psychiatric Presentation of Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Limbic Encephalitis.- 31. Case 31: Limbic Encephalitis.- 32. Case 32: Hashimoto Encephalitis.- Section IV. Nuclear Medicine Cases of Brain Tumors and Miscellaneous.- 33. Case 33: Somatostatin Receptor Targeted PET to differentiate radiation necrosis from a meningioma recurrence.- 34. Case 34: Somatostatin Receptor therapy in a grade II Meningioma.- 35. Case 35: Postoperative Meningioma.- 36. Case 36: Meningioma with Difficult Delineation on MRI.- 37. Case 37: Optic Nerve Sheath Meningioma (ONSM).- 38. Case 38: Pseudoresponse in Glioblastoma.- 39. Case 39: Progressive Glioma.- 40. Case 40: Primary Diagnosis of a Glioblastoma with atypical presentation on MRI.- 41. Case 41: Distinguishing treatment-related changes from true progression in IDH-Mutant glioma using dynamic amino acid PET imaging.- 42. Case 42: Primary Brain Lymphoma.- 43. Case 43: Neurolymphomatosis.- 44. Case 44: Atypical Teratoid Rhabdoid Tumor (ATRT): Identification of Altered Cerebrospinal Fluid Circulation Impacting Intrathecal Chemotherapy.- 45. Case 45: Suspected Recurrence of Brain Metastasis After Radiotherapy.- 46. Case 46: [18F]FET PET and MRI in patients with corticotrope adenoma: report of two cases.- 47. Case 47: Contribution of [18F]FET PET in the diagnosis with leptomeningeal metastases.- 48. Case 48: Initial characterization of a newly diagnosed brain tumor with dynamic amino-acid PET imaging.- 49. Case 49: Theranostics for brain tumors.- 50. Case 50: [18F]FET PET/MR in Rosette-forming glioneuronal tumours (RGNTs).- 51. Case 51: Tumefactive Multiple Sclerosis Lesions (TMS).- 52. Case 52: PET imaging in Neuro-vascular disease.- 53. Case 53: Second generation tau-PET in a case with arteriovenous malformation and mild cognitive impairment.

About the author

Andrea Varrone is Professor of Molecular PET at Karolinska Institutet. Andrea Varrone is a Nuclear Medicine physician with a PhD in Functional radioisotopic imaging. He is Head of the Division of Imaging Core Facilities at the Department of Clinical Neuroscience at Karolinska Institutet and Scientific Director of the Core Facilities Autoradiography, Radiopharmacy, and Brain Molecular Imaging Centre. Prof. Varrone is Research Group Leader for Molecular Imaging in Neurodegenerative Disorders with special focus on the study of patients with movement disorders and he is an expert in Translational PET imaging.
Silvia Morbelli is Full Professor of Nuclear Medicine at the University of Turin and Director of the Nuclear Medicine service of AOU Città della Salute e della Scienza di Torino. She has a PhD in Applied Neurosciences and she made contributions related to the use of neuroimaging tools as diagnostic and prognostic biomarkers in the earliest and preclinical stages of Neurodegenerative Dementia and Parkinsonian Syndromes. 
Valentina Garibotto is Director of the Division of Nuclear Medicine and Molecular Imaging at the Geneva University Hospitals and Professor and Director pf the Department of Radiology and Medical Informatics at the Geneva University. Prof. Garibotto has a large clinical expertise in molecular imaging and coordinates multiple clinical trials on the validation of novel PET tracers, namely for the diagnostic assessment and physiopathological investigation of cognitive disturbances.

Summary

This book, in its 2nd edition, is a collection of cases with challenging diagnosis, in which nuclear medicine examinations have been particularly helpful for the clinicians to perform the final diagnosis or to follow-up the patient. The cases selected are primarily in patients with neurodegenerative disorders, epilepsy and brain tumors. Authors have been selected from internationally recognized experts in the field of Neuroimaging in neurology. All authors have large experience as clinicians and as teachers within the Nuclear Medicine community.
The volume includes cases related to emerging topics such as theranostics for brain tumors and new emerging scenarios for brain PET imaging in the era of Alzheimer’s disease modifying drugs.
The book is intended for nuclear medicine specialists as well as clinicians to provide guidance in the interpretation of neurology cases in the clinical settings, particularly with regards to correct approach to the interpretation of diagnostic imaging procedures.

Product details

• Assisted by: Silvia Daniela Morbelli (Editor), Valentina Garibotto (Editor), Silvia Daniela Morbelli (Editor), Andrea Varrone (Editor)
• Publisher: Springer International Publishing
• Languages: English
• Product format: Hardback
• Release: 17.10.2025
• EAN: 9783032005212
• ISBN: 978-3-032-00521-2
• Illustrations: Approx. 260 p. 137 illus., 117 illus. in color., schwarz-weiss Illustrationen, farbige Illustrationen
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Onkologie, Neurologie und klinische Neurophysiologie, Parkinson, Epilepsy, Neurology, Oncology, Meningiomas, glioma, nuclear medicine, Pituitary Adenoma, brain tumors, Theranostics, Artefacts, Neurodegenerative Dementia, Diseases Modifying drugs for Alzheimer’s Disease, Response to therapy