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Informationen zum Autor Edited by: Robert G. Webster , Division of Virology, Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis Arnold S. Monto , School of Public Health, University of Michigan, Ann Arbor, Michigan Thomas J. Braciale , University of Virginia School of Medicine, Charlottesville, Virginia Robert A. Lamb , Howard Hughes Medical Institute, Department of Molecular Biosciences, Northwestern University, Evanston, Illinois Klappentext The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health.Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain.This new edition is divided into eight key sections, containing chapters co-written by international experts from both the clinical and scientific communities, covering:* Influenza Perspectives* Structure and Replication* Evolution and Ecology* Epidemiology and Surveillance* Immunology* Vaccines and Vaccine Development* Clinical Aspects and Antivirals* Public HealthTextbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners. Zusammenfassung This comprehensive reference provides a complete historical and clinical background of influenza, describing all aspects of its development. It covers genetically modified vaccines and antiviral drugs, with a greater emphasis on laboratory diagnosis to take account of newer techniques, such as near patient tests. Inhaltsverzeichnis List of contributors, ix Foreword to the second edition, xiv Preface to the second edition, xvi Acknowledgments, xvii PART 1 Influenza: Perspective 1 Human influenza: One health, one world, 3 Daniel B. Jernigan and Nancy J. Cox 2 Influenza pandemics: History and lessons learned, 20 Arnold S. Monto and Robert G. Webster PART 2 Structure and replication 3 Structure, disassembly, assembly, and budding of influenza viruses, 37 Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, Gwendolyn Lee, and Z. Hong Zhou 4 The virus genome and its replication, 57 Robert M. Krug and Ervin Fodor 5 Influenza glycoproteins: Hemagglutinin and neuraminidase, 67 Rupert J. Russell, Steven J. Gamblin, and John J. Skehel 6 Proton channels of influenza A and B viruses, 101 Chunlong Ma, Lawrence H. Pinto, and Robert A. Lamb 7 The NS1 protein: A master regulator of host and viral functions, 114 Robert M. Krug and Adolfo García-Sastre 8 Structure and function of the influenza virus replication machinery and PB1-F2, 133 Andrew Mehle and Jonathan A McCullers 9 The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation, 146 Gabriele Neumann and Yoshihiro Kawaoka 10 Pathogenesis, 157 Hans Dieter Klenk, Wolfgang Garten, and Mikhail Matrosovich PART 3 ...
