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Non-obstructive azoospermia (NOA) is characterized by the absence of sperm in the ejaculate due to a failure of the testes to produce sperm and is the cause of infertility in about 1% of adult men. This condition can result from various factors, including genetic abnormalities, hormonal imbalances, and environmental factors. Although NOA can make it difficult for men to conceive a child, there are treatment options available. These include hormonal therapy, surgical procedures, and assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI).
The book begins with an introduction to NOA, including its definition, diagnosis, and epidemiology. The authors then provide a comprehensive discussion on the different aspects of NOA. Topics include endocrine aberrations, the genetic spectrum of NOA, primary and secondary hypogonadism, fertility restoration, surgical approaches for sperm retrieval, and much more. It also explores the psychological and emotional impact of this condition on men and their partners. At the end, the book discusses the most recent international guidelines on NOA as well as what the future holds for NOA, such as experimental therapies, advancements in ART, and new research.
Non-Obstructive Azoospermia: A Comprehensive Guide to Causes, Diagnosis, and Treatment provides a comprehensive understanding of NOA, including its causes, diagnosis, and treatment options. By sharing the latest research, clinical practices, and patient experiences, this book aims to provide a valuable resource for healthcare professionals, researchers, and patients dealing with non-obstructive azoospermia.
List of contents
Introduction to NOA.- Endocrine aberrations of NOA.- Genetic spectrum of NOA.- Differentiation between OA and NOA.- Imaging used in the evaluation of NOA.- Management of primary hypogonadism in men with NOA.- Management of secondary hypogonadism in men with NOA.- Follow-up and Monitoring of Adolescents with Delayed Puberty, Testicular Dysgenesis Syndrome.- Fertility restoration options for prepubertal boys undergoing gonadotoxic treatment.- The Role of Varicocele Repair in Patients with Nonobstructive Azoospermia.- Surgical approaches for sperm retrieval.- Predictors of Sperm Retrieval for Non-Obstructive Azoospermia.- Overview of the technical aspects in the lab.- Management of Non-Obstructive Azoospermia After Prior Failed Treatment.- Emotional and psychological impact of Non-Obstructive Azoospermia (NOA).- Summary of the Most Recent International Guidelines on Non-Obstructive Azoospermia.- Future of non-obstructive azoospermia (NOA).
About the author
Wael Zohdy
Department of Andrology
Cairo University
Cairo, Egypt
Murat Gül
Department of Urology
Selcuk University School of Medicine
Konya, Turkey
Rupin Shah
Department of Urology
Lilavati Hospital and Research Centre
Mumbai, India
Ashok Agarwal
Global Andrology Forum
Moreland Hills, OH, United States
Emeritus Staff, Cleveland Clinic
Cleveland, OH, USA
Summary
Non-obstructive azoospermia (NOA) is characterized by the absence of sperm in the ejaculate due to a failure of the testes to produce sperm and is the cause of infertility in about 1% of adult men. This condition can result from various factors, including genetic abnormalities, hormonal imbalances, and environmental factors. Although NOA can make it difficult for men to conceive a child, there are treatment options available. These include hormonal therapy, surgical procedures, and assisted reproductive techniques such as intracytoplasmic sperm injection (ICSI).
The book begins with an introduction to NOA, including its definition, diagnosis, and epidemiology. The authors then provide a comprehensive discussion on the different aspects of NOA. Topics include endocrine aberrations, the genetic spectrum of NOA, primary and secondary hypogonadism, fertility restoration, surgical approaches for sperm retrieval, and much more. It also explores the psychological and emotional impact of this condition on men and their partners. At the end, the book discusses the most recent international guidelines on NOA as well as what the future holds for NOA, such as experimental therapies, advancements in ART, and new research.
Non-Obstructive Azoospermia: A Comprehensive Guide to Causes, Diagnosis, and Treatment provides a comprehensive understanding of NOA, including its causes, diagnosis, and treatment options. By sharing the latest research, clinical practices, and patient experiences, this book aims to provide a valuable resource for healthcare professionals, researchers, and patients dealing with non-obstructive azoospermia.
