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This book is written in a question-and-answer (Q&A) format and is designed to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. It also serves as an informative and user-friendly reference for information related to using the most up-to-date immunohistochemistry, in situ hybridization, and molecular oncologic pathology in clinical diagnosis. This book improves upon the previous editions by incorporating significant revisions throughout and new additions. Key features and changes in this edition include new chapters on molecular oncologic pathology, over 100 new questions and answers, more refined working antibody panels, and more diagnostic and predictive biomarkers. High-quality color images are also incorporated throughout the book, making it a valuable visual resource. Many chapters have been significantly revised and updated to include relevant new questions, new markers, more refined IHC panels, representative pictures, and current references. There are also many comparisons of data from Geisinger Medical Laboratories to data from the literature, which continue to be a unique feature in this book. The updated Appendix contains detailed antibody information for automated immunostaining procedures for near 250 antibodies.
Written by an international group of experts in the field, Handbook of Practical Immunohistochemistry: Frequently Asked Questions 4th Edition serves as an extensive and practical guide for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
List of contents
Quality management and regulation.- Standardization of diagnostic immunohistochemistry.- Overall review of automated immunohistochemistry.- Applications of rapid immunohistochemistry on frozen tissue sections during intraoperative pathologic diagnosis.- RNA in situ hybridization: Applications in anatomic pathology.- Overview of immunohistochemistry assessment of cancer-related predictive biomarkers and common genetic alterations.- Tissue microarray.- Unknown primary/undifferentiated neoplasm.- Body cavity fluid cytology.- Breast.- Predictive Biomarkers in Breast Cancer: ER, PR and Her-2/neu.- Central nerve system.- Thyroid, parathyroid, and adrenal glands.- Salivary glands and head and neck.- Pleuropulmonary and mediastinal neoplasms.- Uterus.- Ovary.- Prostate gland.- Urinary bladder.- Kidney.- Testis and paratesticular tissues.- Pancreas and ampullae.- Liver, bile ducts and gallbladder.- Upper gastrointestinal tract..- Lower gastrointestinal tract and microsatellite instability (MSI).- Soft tissue and bone tumors.- Lymph node.- Bone Marrow.- Cutaneous lymphomas.- Infectious diseases.- Skin.- Immunofluorescence in skin biopsy.- In situ hybridization in surgical and cytologic specimens.- Molecular oncologic pathology of solid and soft tissue tumors.- Molecular oncologic pathology of hematologic tumors.
About the author
Fan Lin
Department of Laboratory Medicine
Geisinger Health System
Danville, PA
USA
Jeffrey W. Prichard
Department of Laboratory Medicine
Geisinger Medical Center
Danville, PA
USA
Haiyan Liu
Department of Laboratory Medicine
Geisinger Medical Center
Danville, PA
USA
Myra L. Wilkerson
Department of Laboratory Medicine
Geisinger Medical Center
Danville, PA
USA
Yi Ding
Department of Laboratory Medicine
Geisinger Medical Center
Danville, PA
USA
Summary
This book is written in a question-and-answer (Q&A) format and is designed to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. It also serves as an informative and user-friendly reference for information related to using the most up-to-date immunohistochemistry, in situ hybridization, and molecular oncologic pathology in clinical diagnosis. This book improves upon the previous editions by incorporating significant revisions throughout and new additions. Key features and changes in this edition include new chapters on molecular oncologic pathology, over 100 new questions and answers, more refined working antibody panels, and more diagnostic and predictive biomarkers. High-quality color images are also incorporated throughout the book, making it a valuable visual resource. Many chapters have been significantly revised and updated to include relevant new questions, new markers, more refined IHC panels, representative pictures, and current references. There are also many comparisons of data from Geisinger Medical Laboratories to data from the literature, which continue to be a unique feature in this book. The updated Appendix contains detailed antibody information for automated immunostaining procedures for near 250 antibodies.
Written by an international group of experts in the field, Handbook of Practical Immunohistochemistry: Frequently Asked Questions 4th Edition serves as an extensive and practical guide for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
