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The "Pathophysiology of Cancer: An Interdisciplinary Approach" is the twenty-two volume of the "Interdisciplinary Cancer Research" series and a comprehensive volume on the pathophysiology of cancer. The volume starts with a few chapters on the risk of cancer development and carcinogenesis, including mitochondrial energy metabolism in carcinogenesis and the role of mitochondrial DNA mutations in cancer development. The obesity epidemic and cancer risk, urban road dust, genotoxicity, aberrant glycosylation, melatonin, and matrix metalloproteinases as players in cancer development and progression are explained in other chapters. The subsequent chapters discuss vascular endothelium, extracellular vesicles and extracellular matrix, circulating tumor cells, cancer-associated programmed-cell death, and epithelial-to-mesenchymal transition in cancer. Importance of antioxidants, decoding metabolic changes and effects of secondary metabolites in cancer therapy are the subjects of the concluding chapters. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for those who wish to have an update on the pathophysiology of cancer.
List of contents
Micro (Nano) Plastics and the Risk of Cancer Development; Calling for Attention to a Macro Issue.- Cancer: Insight and Strategies to Reduce the Burden.- The Molecular Biology of Cancer Disparities.- The Pattern of Epithelial Carcinogenesis.- Mitochondria as a Key Player In Cancer.- Mitochondrial Energy Metabolism in Carcinogenesis.- Exploring the Role of Mitochondrial DNA Mutations in Cancer Development and Diagnosis.- The Obesity Epidemic and Cancer Risk: Molecular Pathways, Risk Factors and Therapeutic Avenues.- CircRNAs: Orchestrating Obesity, Thermogenesis, and Obesity-associated Cancer Pathways.- Mutagenic Properties of Urban Road Dust. Different Approaches Using Bioindicators.- Relationship between Genotoxicity and Cancer.- Sour Consequences of Aberrant Glycosylation in Cancer Development.- Melatonin and Cancer: New Insights.- Matrix Metalloproteinases as a Key Player in Cancer Progression.- Vascular Endothelium in Cancer.- Extracellular Vesicles: The Dynamic Structural and Functional Network in Aging-Related Diseases and Cancer.- Versatile Component of Extra-Cellular Matrix: Hyaluronan with Dual Application in Understanding Cancer Progression initiation and Cancer Inhibition.- Molecular Markers in Circulating Tumor Cells: Advancing Clinical Precision.- Cancer-Associated Programmed-Cell Death Mechanisms: Extended With Biochemical Markers and Experimental Approaches.- Clinical implications of Epithelial-to-Mesenchymal Transition (EMT) in cancer.- The Unfolded Protein Response Role in Cancer.- PRDM2 in Cancer: Deciphering the Molecular Orchestra of a Multifunctional Regulator.- Importance of Selected Antioxidants in Carcinogenesis and Cancer Therapy.- Decoding Metabolic Changes in Cancer Cells Resistant to Therapy.- A Glance at The Effects of Secondary Metabolites in Fighting Cancer.
About the author
Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research and Technologies, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the Founder of Universal Scientific Education and Research Network (USERN). Prof. Rezaei has already been the Director of more than two hundred research projects and has designed and participated in several international collaborative projects. Prof. Rezaei is the editor, editorial assistant, or editorial board member of more than fifty international journals. He has edited more than one hundred international books, has presented more than a thousand lectures/posters in congresses/meetings, and has published more than 1,500 scientific papers in the international journals.
Summary
The “Pathophysiology of Cancer: An Interdisciplinary Approach” is the twenty-two volume of the “Interdisciplinary Cancer Research” series and a comprehensive volume on the pathophysiology of cancer. The volume starts with a few chapters on the risk of cancer development and carcinogenesis, including mitochondrial energy metabolism in carcinogenesis and the role of mitochondrial DNA mutations in cancer development. The obesity epidemic and cancer risk, urban road dust, genotoxicity, aberrant glycosylation, melatonin, and matrix metalloproteinases as players in cancer development and progression are explained in other chapters. The subsequent chapters discuss vascular endothelium, extracellular vesicles and extracellular matrix, circulating tumor cells, cancer-associated programmed-cell death, and epithelial-to-mesenchymal transition in cancer. Importance of antioxidants, decoding metabolic changes and effects of secondary metabolites in cancer therapy are the subjects of the concluding chapters. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for those who wish to have an update on the pathophysiology of cancer.
