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Ideal for the student seeking a solid understanding of the basic principles in this rapidly developing field, this best-selling text offers a comprehensive introduction to the fundamentals of virology. Featuring an enhanced art program now in full-color, the new edition has been updated throughout, including cutting-edge information on emerging viruses of medical importance and expanded coverage of viral pathogenesis, viral immunology, retroviruses and HIV/AIDS. New chapters have been added dealing with HIV and AIDS, viruses and cancer, generation and use of recombinant viruses and virus-like particles, viral evolution, network biology and viruses, and animal models and transgenics.The third edition is even more comprehensive and accessible, including chapter outlines, revised and expanded review questions, case studies, and cumulative end of section problems, which integrate topics covered in that section and challenge students to synthesize new material.
List of contents
Preface to the First Edition.
Preface to the Second Edition.
Preface to the Third Edition.
Acknowledgments.
Part I: Virology and Viral Disease.
1. Introduction - the Impact of Viruses on Our View of Life 2.
2. An Outline of Virus Replication and Viral Pathogenesis.
3. Virus Disease in Populations and Individual Animals.
4. Patterns of Some Viral Diseases of Humans.
Part II: Basic Properties of Viruses and Virus-Cell Interaction.
5. Virus Structure and Classification.
6. The Beginning and End of the Virus Replication Cycle.
7. Host Immune Response to Viral Infection - The Nature of the Vertebrate Immune Response.
8. Strategies to Protect Against and Combat Viral Infection.
Part III: Working with Virus.
9. Visualization and Enumeration of Virus Particles.
10. Replicating and Measuring Biological Activity of Viruses.
11. Physical and Chemical Manipulation of the Structural Components of Viruses.
12. Characterization of Viral Products Expressed in the Infected Cell.
13. Viruses Use Cellular Processes to Express Their Genetic Information.
Part IV: Replication Patterns of Specific Viruses.
14. Replication of Positive-sense RNA Viruses.
15. Replication Strategies of RNA Viruses Requiring RNA-directed mRNA Transcription as the First Step in Viral Gene Expression.
16. Replication Strategies of Small and Medium-sized DNA Viruses.
17. Replication of Some Nuclear-replicating Eukaryotic DNA Viruses with Large Genomes.
18. Replication of Cytoplasmic DNA Viruses and "Large" Bacteriophages.
19. Retroviruses: Converting RNA to DNA.
20. Human Immunodeficiency Virus Type 1 (HIV-1) and Related Lentiviruses.
21. Hepadnaviruses: Variations on the Retrovirus Theme.
PART V: Viruses: New Approaches and New Problems.
22. The Molecular Genetics of Viruses.
23. Molecular Pathogenesis.
24. Viral Bioinformatics and Beyond.
25. Viruses and the Future - Promises and Problems.
Appendix: Resource Center.
Books of Historical and Basic Value.
Books on Virology.
Molecular Biology and Biochemistry Texts.
Detailed Sources.
Sources for Experimental Protocols.
The Internet.
Technical Glossary.
Index
Report
"This latest revision to the very successful Basic Virology is more than just a simple update... The new chapters are very timely and address current virology research topics including the important issues of molecular pathogenesis and bioinformatics. The text is well written and very understandable with excellent use of photos, diagrams, and tables to highlight and aid in the understanding of difficult issues. Instructors will find the text up to date and the figures readily adaptable to Powerpoint lectures. Students will be pleased to find the text engaging while presenting virology in a clear, concise, and enjoyable manner."
Professor Michael R. Roner, University of Texas, Arlington
