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Informationen zum Autor The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: MOSES V CHAO, Skirball Institute of Biomolecular Medicine, New York, USA Klappentext Novartis Foundation Symposium 289 Growth factors and psychiatric disorders Chair: Moses V. Chao Psychiatric disorders such as depression, bipolar disease and schizophrenia are debilitating illnesses that are influenced by many genetic and environmental factors. While little is known about the neural circuits that underlie such disorders, the convergence of psychiatric, genetic and basic neuroscience research is providing new and exciting insights. In recent years genetic studies have identified several growth factors as susceptibility genes for depression, schizophrenia, and learning and memory. This suggests that psychiatric disorders may be influenced by a small number of genes with multiple actions. These genes will provide clues to the biochemical mechanisms and pathways that underlie these complex disorders. This is the first book to undertake a comprehensive investigation of this research. International leading experts are brought together to discuss the latest findings and look at future directions. Topics addressed include Neuroplasticity and neurotrophic factors. Mechanisms of intracellular trafficking of growth factors. BDNF gene variants in affective disorders. Trophic factors and cognitive functions. Neurotrophins and depression. Schizophrenia genes and neuropathology. Pharmacological treatments of schizophrenia. Growth factors and psychiatric disorders will be of particular interest to psychiatrists, neurologists and geneticists, as well as cell and molecular biologists, and neuroscientists. Zusammenfassung The recent identification of susceptibility genes for schizophrenia! depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. Inhaltsverzeichnis Symposium on Growth factors and psychiatric disorders, held at the Novartis Foundation, London, 20-22 March 2007. Editors: Derek J. Chadwick (Organizer) and Jamie Goode. This symposium is based on a proposal made by Moses Chao. Moses Chao Chair's introduction. Daniel C. Javitt Phenomenology, aetiology and treatment of schizophrenia. Discussion. Jonathan Flint, Sagiv Shifman, Marcus Munafo and Richard Mott Genetic variants in major depression. Discussion. Eero Castrén and Tomi Rantamäki Neurotrophins in depression and antidepressant effects. Discussion. Jinbo Fan and Pamela Sklar Genetics of bipolar disorder: focus on BDNF Val66Met polymorphism. Discussion. David A. Talmage Mechanisms of neuregulin action. Discussion. General discussion I. H. Akil, S. J. Evans, C. A. Turner, J. Perez, R. M. Myers, W. E. Bunney, E. G. Jones, S. J. Watson and other members of the Pritzker Consortium The fibroblast growth factor family and mood disorders. Discussion. Jay N. Giedd, Rhoshel K. Lenroot, Philip Shaw, Francois Lalonde, Mark Celano, Samantha White, Julia Tossell, Anjene Addington and Nitin Gogtay Trajectories of anatomic brain development as a phenotype. Discussion. Bai Lu and Keri Martinowich Cell biology of BDNF and its relevance to schizophrenia. Discussion. Enrico Tongiorgi and Gabriele Baj Functions and mechanisms of BDNF mRNA trafficking. Discussion. Amar Sahay and René Hen
