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Cancer Metabolism: From Molecules to Medicine delivers groundbreaking insights and the latest research into the pivotal role of cancer metabolism in oncology and therapeutic strategies. This book underscores cancer metabolism as a foundational element of cancer biology, predating even the identification of oncogenes and tumor suppressors. It reveals how, unlike normal cells, cancerous cells modify their metabolic pathways to support malignancy, providing new avenues for therapeutic intervention. This book is divided into 16 chapters, delving into the core topics of cancer cell metabolism, metabolic disorders, and autophagy's role in tumor cell metabolism. These subjects illustrate the cellular fitness enhancement via metabolic reprogramming, offering tumors a selective edge through enhanced biosynthesis, altered bioenergetics, and redox balance. This book provides a thorough exploration of how these reprogrammed metabolic processes not only support cancer cell survival and proliferation but also present viable targets for innovative cancer treatments. "Cancer Metabolism: From Molecules to Medicine" serves as an essential resource for scientists and researchers seeking an in-depth understanding of the molecular mechanisms at play in cancer metabolism and its implications for therapy. Additionally, clinicians will find value in the comprehensive coverage of how these metabolic insights translate into novel treatment strategies, bridging the gap between basic research and clinical application. The book's focus on metabolic pathways as therapeutic targets offers practitioners new tools for combating cancer, making it a must-read for both the scientific and medical communities aiming to advance their knowledge and therapeutic capabilities in the dynamic field of cancer metabolism.
List of contents
1. An introduction to cancer metabolism
2. Cancer development and metabolic disorders: Potential Role of metabolic disorders in cancer progression.
3. The New Metabolic Therapy: A Key to a Revolutionary Approach to Cancer Treatment
4. The changing molecular nature of autophagy in cancer metabolism
5. Autophagy and tumor cell metabolism as potential treatment approaches
6. The role of autophagy in the control of cancer and its therapeutic applications at the present time
7. Cancer-associated fibroblasts and autophagy: biology and targeting
8. Mechanisms of signal transduction in solid tumor metabolic dysregulation
9. Cancer medication development based on autophagy and metabolic control
10. Involvement of mitophagy in metabolic reprogramming in tumors and cancer stem cells
11. Changes in Glycolysis and Lipid Metabolism as Molecular Properties of Cancer Cells
12. Cancer metabolism molecules and pathways elucidated and therapeutic implications
13. Molecular understanding of cancer metabolism: Metabolic interactions within tumor microenvironments, and therapeutic implications
14. Targeting cancer metabolism as a potential therapeutic strategy
15. Metabolic Pathways in Cancer: Phenotype, Signalling, and Potential Therapeutic Agents
16. Cancer Metabolism: Immune System Regulation and Metabolism Mechanisms in Cancer Development
About the author
Dr. Gautam Sethi is a tenured Associate Professor in Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore. The focus of his research over the past few years has been to elucidate the mechanism(s) of activation of oncogenic transcription factors by carcinogens and inflammatory agents and the identification of novel inhibitors of these proteins for prevention of and therapy for cancer. The findings of his research work have so far resulted several publications in high impact factor peer reviewed journals and many international awards. He also serves as an editorial board member for over more than 15 international journals
