Immunotherapies for Neurologic Diseases: Volume 214

Immunotherapies for Neurologic Diseases, Volume 214 explores how neuroimmunotherapies intervene by targeting key molecules and pathways responsible for tissue damage in the central and peripheral nervous systems. The book details approved treatments that modulate T-cell signaling, antigen presentation, B cells and their trophic factors, autoantibodies, Fc receptors, complement, cytokines, and cell adhesion molecules. Each chapter includes clear explanations and illustrations, helping clinicians understand the mechanisms of these drugs in autoimmune neurological diseases. The volume serves as a practical and comprehensive guide, making complex therapeutic approaches accessible to medical professionals and students.

The second section highlights the latest therapies for major autoimmune neurological diseases, offering step-by-step algorithms and escalation strategies for selecting optimal treatments. Controversies and uncertainties in therapy choices are discussed by leading experts, while additional chapters address emerging immunotherapeutic approaches for neurodegenerative diseases and the evolving concept of treating autoimmune pain. The book also covers practical applications of traditional immunosuppressants, IVIg, and targeted monoclonal antibodies, with dedicated chapters on conditions such as encephalitis, NMOSD, multiple sclerosis, and stiff person syndrome.

List of contents

1. Introduction to Neuroimmunotherapies: An impressive progress towards targeted effective biologics

Section 1. Special Invited Chapters: Evolution of Autoimmune Neurology
2. Autoimmune encephalitis, Autoimmune dementias and Autoimmune psychotic disorders
3. The History of Paraneoplastic Neurologic Disorders of the CNS, PNS, and Autonomic Nervous Systems: Perspective on the Past Towards a Brighter Future

Section 2. Basic principles of immune activation in neurological diseases as related to targeted immunotherapies
4. Role of B cells and pathogenic autoantibodies in autoimmune CNS and PNS Neurologic diseases
5. Role of complement in neurological autoimmunities: why need to target complement activation for effective immunotherapy
6. Paraneoplastic autoimmune neurological disorders and role of immune checkpoint inhibitors

Section 3. Immunotherapeutic agents in Autoimmune Neurological Diseases: Current and evolving biologics
7. The evolution and current status of anti-B cell therapies in autoimmune Neurologic diseases
8. Evolving targeted biologics against T cells, cytokines and intracellular immune targets for multiple sclerosis with implications in other autoimmune neurological diseases
9. FcRn inhibitors: a new era in neurotherapeutics
10. Intravenous Immunoglobulin (IVIg) use in Neurology
11. HSCT for Multiple sclerosis: Improving understanding and addressing misconceptions
12. Autonomic nervous system autoimmunity and proposed immunotherapies

Section 4.¿ Immunotherapies for specific Neurological Diseases (how do I do it): A step-by step approach based on evidence-based indications with a view to the future
13. Immunotherapies on Autoimmune Encephalitis
14. Immunotherapies in Relapsing-remitting Multiple sclerosis
15. Immunotherapies in progressive Multiple sclerosis
16. Disease Modifying Therapy in Pediatric Multiple Sclerosis
17. Immunotherapies for neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
18. Immunotherapies in Autoimmune Movement Disorders and Cerebellar Ataxia
19. Immunobiology and Immunotherapies in Stiff-person syndrome and GAD antibody-spectrum disorders: Present and future therapeutic prospects
20. Immunotherapies on Guillain-Barre syndrome and other Acute Autoimmune neuropathies
21. Immunotherapies in CIDP and other Chronic Autoimmune Neuropathies
22. Immunotherapy considerations for distal sensory-predominant and small fiber peripheral neuropathies
23. Immunotherapies in Autoimmune neuromuscular Junction disorders: Acute and Chronic management
24. Immunotherapies in Autoimmune Inflammatory Myopathies: Rationale and therapeutic updates
25. The Future Unfolded: CAR T Cells and the Transformation of Treatment Algorithms in Autoimmune Neurology

About the author

Dr. Marinos Dalakas is Professor of Neurology and Director of the Neuromuscular Division at Thomas Jefferson University School of Medicine in Philadelphia. He is Professor of Neurology and Chief of the Neuroimmunology Laboratory in the Department of Pathophysiology at the University of Athens Medical School in Athens, where he has been Emeritus Professor since 2016. Dr. Dalakas is an appointed member in various scientific societies and is a member of the American Neurological Association, the American Academy of Neurology, the European Neurological Society, and the International Society of Greek Neuroscientists, among other professional organizations.

Dr. Dalakas has published widely. His areas of research are broad and include neuroimmunology, neurovirology, genetics, and immunotherapies in neurologic diseases. He has focused on neuropathies, myopathies, dystrophies, ALS, multiple sclerosis, and various autoimmune neurological disorders, with the application and design of new treatments.

He completed a 3-year fellowship training in neuromuscular diseases at the Medical Neurology Branch of the NINCDS in Bethesda, Maryland and an additional 5-year training in Neuroimmunology/Neurovirology at NINDS. He subsequently served as Chief of the Neuromuscular Diseases Section of the NINDS, NIH, a position he held for 20 years before joining Thomas Jefferson University.

Product details

• Publisher: Elsevier
• Languages: English
• Product format: Hardback
• Release: 02.01.2026
• EAN: 9780323908870
• ISBN: 978-0-323-90887-0
• Series: Handbook of Clinical Neurology
• Subjects: Natural sciences, medicine, IT, technology > Biology > Miscellaneous; Medical research, METABOLISM, Endocrinology, MEDICAL / Neurology, MEDICAL / Research, PSYCHOLOGY / Neuropsychology, Neurology & clinical neurophysiology, Neurosciences, Neurology and clinical neurophysiology