ATP - From Neurotransmission to Cancer Therapy

ATP: Extracellular Communication in Health And Disease delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the "Molecular Mediators in Health and Disease" series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.

List of contents

Part I - Introduction to extracellular ATP
1. History of ATP and purinergic signalling
2. Extracellular ATP in normal biology

Part II - Molecular biology of extracellular ATP signalling
3. Extracellular ATP
4. P2X receptors
5. P2Y receptors
6. Regulation of extracellular ATP by ectonucleotidases

Part III - Extracellular ATP in organ function
7. Extracellular ATP and the oral cavity
8. Extracellular ATP and blood vessels
9. Extracellular ATP and the heart and carotid body
10. Extracellular ATP and the lung
11. Extracellular ATP and metabolism
12. Extracellular ATP and the gastrointestinal tract
13. Extracellular ATP and the liver
14. Extracellular ATP and the pancreas
15. Extracellular ATP and the kidneys
16. Extracellular ATP and the bladder
17. Extracellular ATP and the central nervous system
18. Extracellular ATP and the peripheral nervous system
19. Extracellular ATP and the eye
20. Extracellular ATP and the ear
21. Extracellular ATP and the reproductive organs
22. Extracellular ATP and the skin
23. Extracellular ATP and the bone
24. Extracellular ATP and skeletal muscle
25. Extracellular ATP and haematopoietic stem and progenitor cells
26. Extracellular ATP and platelets
27. Extracellular ATP and red blood cells
28. Extracellular ATP and innate immune cells
29. Extracellular ATP and adaptive immune cells

Part IV - Pharmacology of extracellular ATP signalling
30. Extracellular ATP and P2X receptors)
31. Extracellular ATP and P2Y receptors

Part V - Extracellular ATP in non-mammalian biology
32. Extracellular ATP in fish
33. Extracellular ATP in primitive species
34. Extracellular ATP in plants

Part VI - Extracellular ATP in Disease
35. Extracellular ATP in aged-related disorders
36. Extracellular ATP in cardiovascular disorders
37. Extracellular ATP in respiratory disorders
38. Extracellular ATP in gastrointestinal disorders
40. 39. Extracellular ATP in brain diseases
41. Extracellular ATP in neurodegenerative disorders
42. Extracellular ATP in psychiatric disorders
43. Extracellular ATP in pain
44. Extracellular ATP in other sensory disorders
45. Extracellular ATP in infectious disease
46. Extracellular ATP in inflammatory disorders
47. Extracellular ATP in cancer
48. Extracellular ATP and future directions

About the author

Professor Ronald Sluyter received training in biochemistry and immunology. After completing his BAppSc (University of Technology, Sydney, Australia) and PhD (University of Sydney), he worked as a Research Fellow (2000-2003) and Senior Research Fellow (2003-2007) with the late Professor James Wiley at Nepean Hospital. Since 2008 he has held a tenured Aacdemic position at the University of Wollongong, being promoted to Professor in 2020. He is the author of over 137 original articles and book chapters. He has graduated over 16 graduate students.
Dr Jennie Cederholm received training in biomedical science, physiology and neuroscience. After completing her MSc (Linköping University, Sweden) and PhD (University of South Australia, Adelaide), she worked as a Research Officer (2007-2011) in what is today Neuroscience Research Australia (NeuRA). In 2011, she joined the laboratory of Professor Gary Housley as a Postdoctoral Fellow at UNSW Sydney. She holds a tenured Academic position since 2020 and was promoted to Senior Lecturer in 2021. She is the author of 26 refereed scientific publications. She has graduated 8 Honours students and is currently supervising 2 Honours students and a PhD student.
Associate Professor Leanne Stokes received training in physiology and pharmacology. After completing her MRes and PhD in immunology (University of Birmingham, UK), she worked as a postdoctoral researcher officer (2003-2006) at the University of Sheffield. In 2007, she joined the laboratory of the late Professor James Wiley as a Postdoctoral Fellow at University of Sydney before gaining independence through an NHMRC new investigator award (2009). In 2013 she moved to RMIT to take a position as a Vice-Chancellors Research Fellow (2013-2015). She holds a tenured Academic position since 2015 at the University of East Anglia (UEA) and was promoted to Associate Professor in 2020. She is the author of 54 refereed scientific publications. She has graduated 3 PhD students and is currently supervising an MSci student and a PhD student.
Prof. H Ulrich is Full Professor and Head of the Laboratory of Neuroscience at the Institute of Chemistry of the University of São Paulo, Brazil. He is a pioneer in the investigation of purinergic signaling in neuroinflammation, neurogenesis and neurodegeneration. He is a founding member of the Brazilian Purine Club (Brazilian Society of Purinergic Signaling), Vice-President (2010-2012) and President (2012-2018 and 2021-2024) of the society and has chaired many congresses of the Brazilian Purine Club. He is Associate Editor of several peer-reviewed journals, including Purinergic Signalling. He has published more than 260 peer-reviewed manuscripts (>10,000 citations, H index: 52), 31 book articles and 5 books and is inventor in various patents. He was recently awarded with the Brazil Fulbright Global Health Chair at Rutgers Medical School.
Associate Professor Srdjan Vlajkovic received training in medicine, immunology, and neuroscience. He worked at the Department of Physiology, University of Auckland as a Research Fellow and Senior Research Fellow and now holds a tenured academic position at the University of Auckland. He authored 88 original articles and book chapters and supervised 38 graduate students to completion. Dr Vlajkovic guest-edited several Special Issues in international journals and is currently the Academic Editor of the International Journal of Molecular Sciences and Frontiers journals.
Prof. Y Tang is a Full Professor and Dean of the School of Health and Rehabilitation of Chengdu University of Traditional Chinese Medicine. He is the founding member of the International Joint Research Center on Purinergic Signalling of Sichuan Province of China and the Co-chair of China Purine Club. He is Associate Editor of Purinergic Signalling. He is the author of over 157 publications and book chapters. He has graduated over 29 graduate students.

Product details

• Assisted by: Jennie Cederholm (Editor), Ronald Sluyter (Editor), Leanne Stokes (Editor), Yong Tang (Editor), Ulrich Henning (Editor), Srdjan Vlajkovic (Editor)
• Publisher: Elsevier
• Languages: English
• Product format: Paperback / Softback
• Release: 01.01.2026
• EAN: 9780443302503
• ISBN: 978-0-443-30250-3
• Series: Molecular Mediators in Health and Disease: How Cells Communicate
• Subjects: Natural sciences, medicine, IT, technology > Biology > General, dictionaries; SCIENCE / Life Sciences / Cell Biology, Cellular biology (cytology)