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Definitive reference on studying proteome biomarkers through cardiovascular disease pathophysiology and applied mass spectrometry Cardiovascular Proteomics Techniques explores the intersection of cardiovascular disease pathophysiology and applied mass spectrometry to study proteome biomarkers. Leading experts provide a comprehensive overview of the physiopathology of cardiovascular system diseases, along with insights into their etiology and pathogenesis through proteomics. The book features thirty chapters covering a range of topics, including mass spectrometry, proteomics, atherosclerosis, heart biology, cardiovascular diseases, experimental models, network analysis, international proteomic initiatives, clinical proteomics, and sex and gender proteomics.
Cardiovascular Proteomics Techniques also includes in depth discussions on:
- Antibody-based technologies for multiplexed protein detection and quantification, and their complementary role to mass spectrometry-based protein profiling.
- New findings from proteomic analysis regarding the pathogenesis of atherosclerosis.
- Emerging insights into the pathobiology of acute coronary syndromes.
- Network medicine as a new paradigm for cardiovascular disease research and beyond, with potential applications in drug repurposing.
- Recent advances in cardiovascular plasma proteomics and previously unexplored cardiac diseases, such as Takotsubo syndrome.
This book is ideal for researchers in mass spectrometry, proteomics, life sciences, and cardiovascular studies,
Cardiovascular Proteomics Techniques aims to enhance our understanding of cardiovascular issues among clinicians and stimulate future developments in proteomics for the diagnosis and treatment of cardiovascular diseases.
List of contents
List of Contributors xvii
1 Basic Concepts in Mass Spectrometry 1
2 Overview of Antibody-Based Technologies for Multiplexed Protein Detection and Quantification and Their Complementarity to Mass Spectrometry-Based Protein Profiling 31
3 General Features of the Cardiovascular System 67
4 Albumin and Cardiovascular Diseases 81
5 Platelets 109
6 The Role of Proteomics in Extracellular Vesicles Research in Cardiovascular Disease 141
7 Proteomics of Human Lipoproteins in Cardiovascular Diseases 183
8 Extracellular Matrix in Cardiovascular Pathophysiology 221
9 Pathogenesis of Atherosclerosis 261
10 Emerging Insights into the Pathobiology of Acute Coronary Syndromes 289
11 Valvular Heart Disease, from Physiopathology to Biomarker Discovery 321
12 Pathophysiology of Heart Failure 349
13 Diseases of the Aorta, Recent Insights 379
14 Unveiling Sex and Gender Differences in Cardiovascular Diseases 401
15 Trends in Mass Spectrometry Imaging for Cardiovascular Diseases 441
16 Network Medicine: A New Paradigm for Cardiovascular Disease Research and Beyond 459
17 Recent Advances in Cardiovascular Plasma Proteomics 497
18 Unexplored Cardiac Diseases: Takotsubo Syndrome 535
Index 553
About the author
Cristina Banfi, PhD has been leading the Laboratory of Functional Proteomics, Metabolomics and Network Analysis at Cardiologic Monzino Center in Milan since 2005. She has served as the Director of Target Discovery since 2020 and is Adjunct Professor of Biomedical Omics at the University of Milan. Dr. Banfi is a leading authority in the field of proteomics, having published more than 200 peer-reviewed papers and book chapters. Additionally, she acts as a reviewer for several prominent journals.
