Mechanism of Functional Expression of the Molecular Machines

This brief discusses the mechanism of functional expression of a protein or protein complex utilizing the ATP hydrolysis cycle or proton-motive force from a unique point of view focused on the roles of water. A variety of processes are considered such as the unidirectional movement of a linear-motor protein along a filament, insertion of an unfolded protein into a chaperonin and release of the folded protein from it, transport of diverse substrates across the membrane by a transporter, and directed rotation of the central subunit within a rotatory motor protein complex. These topics are discussed in a unified manner within the same theoretical framework. The author argues that water plays imperative roles in the functional expression of these molecular machines. A pivotal factor is the entropic force or potential originating from the translational displacement of water molecules coexisting with the molecular machines in the entire system.

List of contents

Introduction.- Importance of Translational, Configurational Entropy of Water.- Molecular Machines.- Concluding Remarks: Mechanism of Functional Expression Common in the Molecular Machines.

Product details

• Authors: Masahiro Kinoshita
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 22.06.2016
• EAN: 9789811014840
• ISBN: 978-981-10-1484-0
• No. of pages: 70
• Dimensions: 158 mm x 237 mm x 4 mm
• Weight: 137 g
• Illustrations: X, 70 p. 30 illus., 24 illus. in color.
• Series: SpringerBriefs in Molecular Science
• Subject: Natural sciences, medicine, IT, technology > Chemistry > Physical chemistry