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It has long been known that the host responses to apoptosis, especially those that govern inflammation and immunity, lie at the heart of many normal physiological processes in multiple organ systems. That such responses are likely to play key roles in the pathophysiology of many disease states has become increasingly clear. The capacity of apoptosis to influence tissue microenvironments and produce systemic effects, in addition to the relevance of other cell death processes including necroptosis, pyroptosis and ferroptosis, has many implications for regulating inflammatory mechanisms.
This book provides a diverse exploration of molecular, cellular, and organismal responses to dying cells, and offers new perspectives on the roles of apoptosis and other cell-death programs in the regulation of inflammation in normal physiological processes and in disease states. The different chapters, written by top researchers in their respective fields, emphasize the responses to cell death and how the underlying mechanisms of cell-death programs are coupled to those responses. This is a unique and timely resource for researchers, scientists, and students in the biomedical sciences.
List of contents
Elephants in the room.- Molecular cell biology of apoptosis in health and disease.- Efferocytosis in homeostasis.- Messages from beyond the grave: How can Drosophila help us to understand the consequences of apoptosis.- Metabolic implications of efferocytosis during inflammation.- Apoptosis and cell clearance in skin wound healing.- Of tingible bodies and starry skies: Control of normal and malignant tissues through apoptotic cell-dependent communication (ACDC).- Cell death and infection: Implications for host and microbe.- For better or worse The impact of necrotic cell death modalities.- Entosis in health and disease.
Summary
Elephants in the room.- Molecular cell biology of apoptosis in health and disease.- Efferocytosis in homeostasis.- Messages from beyond the grave: How can Drosophila help us to understand the consequences of apoptosis.- Metabolic implications of efferocytosis during inflammation.- Apoptosis and cell clearance in skin wound healing.- Of tingible bodies and starry skies: Control of normal and malignant tissues through apoptotic cell-dependent communication (ACDC).- Cell death and infection: Implications for host and microbe.- For better or worse The impact of necrotic cell death modalities.- Entosis in health and disease.
