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By providing an authoritative introduction to concepts, methods and applications in matching donors and acceptors of transplanted cells and organs, this guide provides medical researchers and practitioners with the key knowledge for performing meaningful histocompatibility analyses and thereby improving the outcome of transplantation therapies across all medical fields. The authors are all members of the European and/or American Societies for Immunogenetics and have been instrumental in developing commonly accepted standards and therapeutic recommendations.
List of contents
Part 1: BIOLOGICAL BASICS
(1) Innate Immune Defence
(2) Specific Immune Defence
(3) The HLA/MHC System
(4) The HNA System
(5) Natural Killer Cell Receptors
(6) The HPA System
(7) Other Polymorphic Systems
Part 2: CLINICAL APPLICATIONS
(8) Basic Concepts of Organ Transplantation
(9) Basic Concepts of Organ Rejection
(10) Treatment of Organ Rejection
(11) Stem Cell Transplantation
(12) Stem Cell Transplantation from Unrelated Donors
(13) Chimerism Testing in Stem Cell Transplantation
(14) Disease Associations with HLA Alleles
(15) Drug Associations with HLA Alleles
(16) Diseases in the Field of Transfusion Medicine
Part 3: METHODS IN HISTOCOMPATIBILITY AND IMMUNOGENETICS
(17) Isolation and Purification of Test Material
(18) HLA-Antibody Determination
(19) Low/ medium-resolution HLA typing
(20) High-resolution HLA Typing
(21) Crossmatching in Transplantation
(22) Determination of Antibodies and Typing in the HPA System
(23) KIR Genotyping
(24) Determination of Antibodies and Typing in the HNA System
(25) Determination and Typing of Other Polymorphic Systems
Part 4: REGULATORY ASPECTS
(26) Regulations in Histocompatibility and Immunogenetics: Accreditation, External Proficiency Testing, Quality Management
Glossary and Index
About the author
Volker Oberle, PhD, is the EFI-Director of the Laboratory for Transplantation Immunology at Jena University Hospital. He studied chemistry and biochemistry at the Universities of Freiburg and Halle-Wittenberg, is a DGI-certified Fachimmungenetiker and holds an ESHI diploma.
Summary
By providing an authoritative introduction to concepts, methods and applications in matching donors and acceptors of transplanted cells and organs, this guide provides medical researchers and practitioners with the key knowledge for performing meaningful histocompatibility analyses and thereby improving the outcome of transplantation therapies across all medical fields. The authors are all members of the European and/or American Societies for Immunogenetics and have been instrumental in developing commonly accepted standards and therapeutic recommendations.
