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Pharmacological fMRI: Methods and Applications give a comprehensive survey of the cutting-edge field of pharmacological fMRI - the use of functional Magnetic Resonance Imaging to investigate the effects of drugs on the brain. It introduces the basic concepts, focusing on methodological topics and issues, and gives a summary of current research focused on particular drugs, clinical conditions, or drug classes (including psychedelics, pain, anti-depressants). It concludes by pointing the way forward by outlining current challenges in the field and how they might be resolved.
Pharmacological fMRI: Methods and Applications provides the student and researcher with a complete picture of the current methods and applications in pharmacological fMRI, enabling them to apply the principles and approaches to their own work. Reflecting the cross disciplinary nature of the field, this book is suitable for students and researchers in the fields of biomedical engineering, pharmacology, neuroscience, clinical medicine, and psychology.
List of contents
1. Introduction
2. Methods in Pharmacological fMRI
3. Pre-clinical pharmacological Authors
4. Anti-depressants
5. Classic Psychedelics
6. Non-classic psychedelics
7. Pain and analgesics
8. Addiction
9. Hormones
10. Cannabis and Cannabinoids
11. fMRI in drug development
12. The future of pharmacological fMRI
About the author
Matt Wall graduated with a degree in Natural Sciences from the University of Cambridge. He completed his PhD with Professor David Barford in the Department of Structural Biology at the Institute of Cancer Research. He was a Sir Henry Wellcome Fellow with Professor John Scott FRS (University of Washington, Dept. Pharmacology) prior to starting his group at UCL.
Mitul Mehta joined King’s College London as a post-doctoral researcher in Neuroimaging in 2003 with the aim of setting up a research group focused on pharmacological neuroimaging using MRI methodology. He worked with positron emission tomography at Imperial College for a number of years as an MRC Training Fellow before moving to King’s. A Wellcome Trust Value in People Award enabled the transition. His work was recognised by the British Association for Psychopharmacology Young Investigator Award. At King’s his group brought quantitative methods to identify drug mechanisms and classify different compounds and used classic tracking methods (phMRI) to develop assays of drug modulation. These methods are utilised to understand existing compounds as well as assay novel compounds and we have tested various mechanisms, including in collaboration with the pharmaceutical industry.
