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Informationen zum Autor Adam J Mead PhD, FRCP, FRCPath, FMedSci Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK Michael A Laffan DM, MRCP, FRCPath Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK Graham P Collins DPhil, FRCP, FRCPath Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK Deborah Hay DPhil, MRCP, FRCPath Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK Consulting Editor A Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci Emeritus Professor of Haematology, University College London, London, UK Honorary Consultant Haematologist, Royal Free Hospital, London, UK Klappentext The latest edition of the key haematology text Haematology, the study and treatment of blood and bone marrow disorders, is a rich and complex discipline that consistently produces cutting-edge medical research. Since 1972, Hoffbrand's Postgraduate Haematology has acted as the foundational overview and reference text for this subject, introducing generations of trainees and medical residents to the pathogenesis, clinical and laboratory features, and management of blood disorders. The eighth edition of Hoffbrand's Postgraduate Haematology, now with a new editorial team including leading clinicians and researchers, promises to continue this tradition of excellence with a fully updated text. Lavishly illustrated, comprehensive, and thoughtfully referenced, it is an indispensable resource. Readers of the eighth edition of Hoffbrand's Postgraduate Haematology will also find: Four-color illustrations and photomicrographs of blood cells and tissues throughout to support key topicsNew sections analysing recent advances in next generation sequencing, genome editing, clonal haematopoiesis, anticoagulant drugs, diagnostic laboratory tools, and moreCompanion website with downloadable figures and other tools Hoffbrand's Postgraduate Haematology is ideal for all postgraduate trainees or residents in haematology, as well as for clinicians and practitioners looking for a reference work on the subject and a guide to the latest research. Inhaltsverzeichnis About the Editors viii Contributor's List x Preface to the eighth edition by Adam J Mead xiv Preface to the eighth edition by A Victor Hoffbrand xv Preface to the first edition xvi About the companion website xvii Part I General principles of haematology 1 1 Human stem cells and haemopoiesis 3 Petter S Woll and Adam J Mead 2 Phagocytes 15 Fernando O Martinez, Giuseppe Teti and Siamon Gordon 3 Erythropoiesis in the human 43 Douglas R Higgs, Christian Babbs and Mira Kassouf 4 Lymphocyte development and function 56 Sean Hua Lim 5 The spleen 71 Catherine Hildyard and Daniel Royston 6 Cancer immunotherapy 82 Charlotte O'Brien-Gore, Sophie Papa and Shahram Kordasti 7 Clinical applications of gene editing and therapy 96 Mohsin Badat and James Davies 8 Application of next-generation sequencing in haematology 106 Angela Hamblin and Adele Timbs 9 The molecular basis of haematological malignancies 121 Meng Wang, Niccolo Bolli and George S Vassiliou 10 Laboratory diagnosis of haematological neoplasms 142 Barbara J Bain and Torsten Haferlach Part II Red blood cell disorders and blood transfusion 163 11 Iron metabolism, iron deficiency and disorders of haem synthesis 165 Clara Camaschella and Chaim Hershko 12 Iron o...
