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This comprehensive volume covers all aspects from the historical discovery of the filarial parasite Loa loa to the latest diagnostics and therapies for all forms of pathology used at the point of care. Current developments in these areas are also highlighted. Expert authors present the epidemiological impact of loiasis and the basic mechanisms underlying the disease in native populations and nonresidents of endemic areas. In addition to particulars on the immunology of the parasite, its general and molecular biology, the clinical manifestation is also described in detail. Both common and atypical clinical manifestations are considered. This book concludes with an outlook on further research and targeted eradication of the disease.
Loa loa, known as the "eye worm", is endemic in the rural populations of several African countries and is transmitted by rainforest deerflies. It displays impressive immune adaptation with a wide range of clinical symptoms that remain largely unexplored. The characteristics of this nematode make it of great interest to physicians and researchers specializing in infectious diseases, epidemiology, and immunology. In addition, students and family physicians working with African immigrants and travelers should know about this parasite.
Loiasis is a prime example of a neglected disease under the conditions of international health efforts in our globalized world. The present work is intended to promote progress in this field, making it a valuable read within the scope of the UN Sustainable Development Goal 3 (Good Health and Well-Being).
List of contents
The history of the Loa loa parasite, its biology and experimental models.- Epidemiology and Public health importance.- The role of human host and parasite genetics in the outcome of loiasis.- Loiasis disease typical and atypical clinical manifestations, burden and local aspects of the disease.- Clinical aspects: Treatment of simple and complicated forms of loiasis.- Diagnosis of Loa loa: from blood identification to innovative approaches.- Immune mechanism in loiasis and interactions with other infections.- The Loa loa genome and potential immunological and therapeutic molecular targets with medicinal plants.
About the author
Jean Paul Akue, PhD,holds a MSc in Parasitology and Medical Entomology, Immunology/Molecular Biology option, from the LSTM (Univ. of Liverpool). He has been a Visiting Scientist at CDC, Parasitic Disease Branch, USA, and a Wellcome Trust’s International Fellow at the University of Glasgow in Scotland. For more than 20 years, he has carried out research on host parasite relationship in Loa loa infection either at CIRMF, in an international Network (INCO DC filarial), or as PI in a Wellcome Trust founded grant. Currently, he is Group Leader at CIRMF for research on Neglected Parasites, including zoonotic species like Toxoplasma gondii, Neospora, and Sarcocystis besides Loa loa. J.P. Akue was also a PI in the AfriqueOne consortium which gathers 15 African and European universities working on zoonoses under the concept of One Health. He has supervised several doctorats and masters. His scientific record includes more than 43 papers, 4 chapters in books, and over 50 communications at international meetings.
Summary
This comprehensive volume covers all aspects from the historical discovery of the filarial parasite Loa loa to the latest diagnostics and therapies for all forms of pathology used at the point of care. Current developments in these areas are also highlighted. Expert authors present the epidemiological impact of loiasis and the basic mechanisms underlying the disease in native populations and nonresidents of endemic areas. In addition to particulars on the immunology of the parasite, its general and molecular biology, the clinical manifestation is also described in detail. Both common and atypical clinical manifestations are considered. This book concludes with an outlook on further research and targeted eradication of the disease.
Loa loa, known as the "eye worm", is endemic in the rural populations of several African countries and is transmitted by rainforest deerflies. It displays impressive immune adaptation with a wide range of clinical symptoms that remain largely unexplored. The characteristics of this nematode make it of great interest to physicians and researchers specializing in infectious diseases, epidemiology, and immunology. In addition, students and family physicians working with African immigrants and travelers should know about this parasite.
Loiasis is a prime example of a neglected disease under the conditions of international health efforts in our globalized world. The present work is intended to promote progress in this field, making it a valuable read within the scope of the UN Sustainable Development Goal 3 (Good Health and Well-Being).
