Fas Signaling

Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.

List of contents

FasL and Fas.- FasL-Independent Activation of Fas.- Role of Ceramide in CD95 Signaling.- Regulation of Fas Signaling by FLIP Proteins.- Fas-Induced Necrosis.- Fas-More Than an Apoptosis Inducer.- Retrograde Fas Ligand Signaling.- FasL and Fas in Liver Homeostasis and Hepatic Injuries.- Fas-Activation, Development and Homeostasis of T Cells.- The FasL-Fas System in Disease and Therapy.- Tools for Activation and Neutralization of Fas Signaling.

Summary

Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.

Product details

• Authors: Harald Wajant
• Assisted by: H. Wajant (Editor), Haral Wajant (Editor), Harald Wajant (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 22.06.2006
• EAN: 9780387321721
• ISBN: 978-0-387-32172-1
• No. of pages: 160
• Weight: 402 g
• Illustrations: VIII, 160 p. 32 illus., 4 illus. in color.
• Series: Medical Intelligence Unit; Medical Intelligence Unit
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Onkologie, B, Medical research, Immunology, Regulation, Medizinische Forschung, INTERNAL MEDICINE, molecular biology, Oncology, proteins, Biomedical and Life Sciences, Biomedical Research, Molecular Medicine