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Less than twenty years ago photolithography and medicine were total strangers to one another.Theyhadnotyetmet,andnotevenlookingeachotherupintheclassi?eds.And then,nucleicacidchips,micro?uidicsandmicroarraysenteredthescene,andrapidlythese strangersbecameindispensablepartnersinbiomedicine. Asrecentlyastenyearsagothenotionofapplyingnanotechnologytothe?ghtagainstd- easewasdominantlytheprovinceofthe?ctionwriters.Thoughtsofnanoparticle-vehicled deliveryoftherapeuticalstodiseasedsiteswereanexerciseinscienti?csolitude,andgrounds for questioning one s ability to think like an established scientist . And today we have nanoparticulatepaclitaxelastheprimeoptionagainstmetastaticbreastcancer,proteomic pro?lingdiagnostictoolsbasedontargetsurfacenanotexturing,nanoparticlecontrastagents forallradiologicalmodalities,nanotechnologiesembeddedinhigh-distributionlaboratory equipment, and no less than 152 novel nanomedical entities in the regulatory pipeline in theUSalone. Thisisatransformingimpact,byanymeasure,withclearevidenceoffurtheracceleration, supported by very vigorous investments by the public and private sectors throughout the world. Even joining the dots in a most conservative, linear fashion, it is easy to envision scenariosofpersonalizedmedicinesuchasthefollowing: patient-speci?cpreventionsupplantinggross,facelessinterventionstrategies; early detection protocols identifying signs of developing disease at the time when thediseaseismosteasilysubdued; personally tailored intervention strategies that are so routinely and inexpensively realized,thataccesstothemcanbesecuredbyeveryone; technologiesallowingforlonglivesinthecompanyofdisease,asgoodneighbors, withoutimpairmentofthequalityoflifeitself. Thesevisionswillbecomereality.Thecontributionsfromtheworldsofsmall-scalete- nologies are required to realize them. Invaluable progress towards them was recorded by the very scientists that have joined forces to accomplish the effort presented in this 4-volume collection. It has been a great privilege for me to be at their service, and at the service of the readership, in aiding with its assembly. May I take this oppor- nity to express my gratitude to all of the contributing Chapter Authors, for their - spired and thorough work. For many of them, writing about the history of their s- cialty?eldsofBioMEMSandBiomedicalNanotechnologyhasreallybeenreportingabout their personal, individual adventures through scienti?c discovery and innovation a sort xxii FOREWORD of family album, with equations, diagrams, bibliographies and charts replacing Holiday pictures....
List of contents
Application of Microarray Technologies.- Electronic Microarray Technology and Applications in Genomics and Proteomics.- Gene Expression Profiling Utilizing Microarray Technology and RT-PCR.- Microarray and Fluidic Chip for Extracellular Sensing.- Cell Physiometry Tools based on Dielectrophoresis.- Hitting the Spot: The Promise of Protein Microarrays.- Use of Electric Field Array Devices for Assisted Assembly of DNA Nanocomponents and Other Nanofabrication Applications.- Peptide Arrays in Proteomics and Drug Discovery.- From One-Bead One-Compound Combinatorial Libraries to Chemical Microarrays.- Advanced Microfluidic Devices and Human Genome Project.- Plastic Microfluidic Devices for DNA and Protein Analyses.- Centrifuge Based Fluidic Platforms.- Sequencing the Human Genome: A Historical Perspective on Challenges for Systems Integration.- Nanoprobes for Imaging, Sensing and Therapy.- Hairpin Nanoprobes for Gene Detection.- Fluorescent Lanthanide Labels with Time-Resolved Fluorometry in DNA Analysis.- Role of SNPs and Haplotypes in Human Disease and Drug Development.- Control of Biomolecular Activity by Nanoparticle Antennas.- Sequence Matters: The Influence of Basepair Sequence on DNA-protein Interactions.- Engineered Ribozymes: Efficient Tools for Molecular Gene Therapy and Gene Discovery.
About the author
Mauro Ferrari is a pioneer in the fields of bioMEMS and biomedical nanotechnology. As a leading academic, a dedicated entrepreneur, and a vision setter for the Nation's premier Federal programs in nanomedicine, he brings a three-fold vantage perspective to his roles as Editor-in-Chief for this work. Dr. Ferrari has authored or co-authored over 150 scientific publications, 6 books, and over 20 US andInternational patents. Dr. Ferrari is also Editor-in-Chief of Biomedical Microdevices and series editor of the new Springer series on Emerging Biomedical Technologies.Several private sector companies originated from his laboratories at the Ohio State University and the University of California at Berkeley over the years. On a Federal assignment as SpecialExpert in Nanotechnology and Eminent Scholar, he has provided the scientific leadership for the development of the Alliance for Cancer Nanotechnology of the National Cancer Institute, the world-largest medical nanotechnology operation to date. Dr. Ferrari trained in mathematical physics in Italy, obtained his Master's and Ph.D. in MechanicalEngineering at Berkeley, attended medical school at The Ohio State University, and served in faculty positions in Materials Science and Engineering, and Civil and Environmental Engineering in Berkeley, where he was first tenured. At Ohio State he currently serves as Professor of Internal Medicine, Division of Hematology and Oncology, as Edgar Hendrickson Professor of Biomedical Engineering, and as Professor of Mechanical Engineering. He is Associate Director of the Dorothy M. DavisHeart and Lung Research Institute, and the University's Associate Vice President for Health Science, Technology and Commercialization.
Summary
Contains contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices with applications to Genomics and Proteomics. This title covers topics such as imaging and sensing for gene detection and use in DNA analysis; including coverage of advanced microfluidic devices.
