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Drug delivery by injecting them through arteries poses unique challenges. The first attempts to treat malignant brain tumors by arterial injections were undertaken soon after World War II. Yet, the applications of arterial delivery in treating neurological diseases have not advanced significantly over the last seventy years. Although arterial drug delivery is used to treat several neurological conditions, its applications, other than for localization of brain functions, remain experimental and are unproven in robust scientific studies. Over the last two decades, interventional radiology has significantly advanced by developing catheter-based devices, but arterial drug development has largely been ignored. This book makes the case for arterial drug development. Unless drugs are developed explicitly for arterial injections, the vast potential of arterial treatments of neurological diseases will remain untapped.
This multi-author book brings together experienced researchers and clinicians to investigate various applications of arterial drug delivery for treating neurological diseases. It's an essential resource for various medical subspecialties related to the field and to advance pharmacological and clinical research with this mode of drug delivery.
List of contents
I. The history of IA drug delivery (Chapter 1).-II. The pharmacokinetics of intraarterial drugs.-The conventional approach to modeling IA drug delivery (Chapter 2).- Flow dynamics of regional drug delivery (Chapter 3).- Flow-controlled kinetics of intraarterial drugs (Chapter 4).- Optical methods to investigate ultrafast IA drug kinetics (Chapter 5).- III. Current applications of IA drugs.-Specific cancers.- Retinoblastomas (Chapter 6).- Metastatic liver cancer ((Chapter 7).- Glioblastomas (Chapter 8).- Locally invasive breast cancers (Chapter 9).- Pelvic malignancy (Chapter 10).- Head and neck tumors (Chapter 11).- Neurological diseases.-Treatment of cerebral vasospasm (Chapter 12).- Stroke and local brain cooling (Chapter 13).- Blood-brain barrier disruption (Chapter 14).- Intraarterial thrombolysis for peripheral vascular disease (Chapter 15).- IV. Experimental applications of IA drugs.-Nanoparticle delivery (Chapter 16).- Carrier-mediated delivery (Chapter 17).- Gene delivery (Chapter 18).-Stem cell delivery (Chapter 19).- V. Technologies to deliver IA drugs.-The development of future intraarterial drugs (Chapter 20).- Balloon occluding catheters for drug delivery (Chapter 21).- Infusion pumps design and challenges (Chapter 22).- Robotic endovascular surgery (Chapter 23).- Self-navigation and artificial intelligence (Chapter 24).- VI. Conclusion: The future of intraarterial Drug Delivery (Chapter 25).
