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Bradykinin: From Vasodilation to Neuroinflammation, the latest release in the
Molecular Mediators in Health and Disease series is a comprehensive guide to the multi-functional peptide bradykinin and its impact across the human body. The early chapters provide an overview of the biosynthesis and metabolism of bradykinin, understanding its receptors and signaling pathways, and the therapeutic value of agonists and antagonists for targeting these. This book explores the role of bradykinin in vascular, renal, and brain function, as well as its influence on various conditions and diseases, including inflammation, pain, cardiovascular disease, renal disease, obesity, ischemic stroke, and infectious diseases, including Covid-19.
In addition to its foundational knowledge, the book includes extensive coverage of bradykinin biochemistry and molecular biology. It highlights the therapeutic potential of bradykinin, making it an ideal reference for researchers working in these fields. The book serves as an invaluable resource for understanding the complex roles of bradykinin and its applications in medical research and treatment.
List of contents
1. Introduction
2. Biosynthesis and metabolism of bradykinin
3. Bradykinin receptors and their signalling pathways
4. Animal models for studying bradykinin receptors
5. Peptide and non-peptide ligands acting at bradykinin receptors
6. Bradykinin in angioedema
7. Bradykinin and its receptors in inflammation
8. Bradykinin in Pain
9. Bradykinin in cardiovascular and renal diseases
10. Bradykinin in hypertension and heart failure
11. Bradykinin and its receptors in neovascularisation
12. Bradykinin in diabetes and obesity
13. Bradykinin in ocular diseases
14. Bradykinin agonists as a mean to increase blood-brain barrier permeability
15. Bradykinin as a central mediator
16. Bradykinin in infectious and parasitic diseases
17. Bradykinin in cancer
About the author
Réjean Couture is currently Full Professor at the Department of Pharmacology and Physiology at the Faculty of Medicine, Université de Montréal in Canada. After completing a PhD in Pharmacology at University of Sherbrooke, Canada, he was awarded Fellowship Awards from the Medical Research Council of Canada (MRC) and the Fonds de la recherche en santé du Quebec (FRSQ) to pursue postdoctoral trainings in Pharmacology at Oxford University and in Neuroscience at McGill University.
He is the author of over 225 original articles, books and book chapters, including 90 directly on kinins. He has supervised close to 60 graduate and postdoctoral students, many of whom now hold significant academic and other positions throughout Canada and internationally.
He is known internationally for his seminal contributions in the field of Bradykinin and Substance P in pain and inflammation and in central autonomic control of blood pressure.
